2. Epigenetics Apoptosis
  3. Histone Demethylase Apoptosis
  4. Bomedemstat hydrochloride

Bomedemstat hydrochloride  (Synonyms: IMG-7289 hydrochloride)

Cat. No.: HY-109169B Purity: 99.94%
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Bomedemstat (IMG-7289) hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat hydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat hydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis.

For research use only. We do not sell to patients.

Bomedemstat hydrochloride Chemical Structure

Bomedemstat hydrochloride Chemical Structure

Size Price Stock Quantity
1 mg USD 144 In-stock
5 mg USD 360 In-stock
10 mg USD 580 In-stock
25 mg USD 1150 In-stock
50 mg USD 1850 In-stock
100 mg USD 2980 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Bomedemstat hydrochloride:

Bomedemstat hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

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  • Purity & Documentation

  • References

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Description

Bomedemstat (IMG-7289) hydrochloride is an orally active and irreversible lysine-specific demethylase 1 (LSD1) inhibitor. Bomedemstat hydrochloride can increase H3K4 and H3K9 methylation, and then alter gene expression. Bomedemstat hydrochloride shows anti-cancer activities, inhibits cancer cell proliferation and induces apoptosis[1][2].

IC50 & Target

KDM1/LSD1

 

In Vitro

Bomedemstat selectively inhibits proliferation and induces apoptosis of Jak2V617F cells by concomitantly increasing expression and methylation of p53[1].
Bomedemstat (50 nM-1 μM; 96 h) enhances survival, induces apoptosis via BCL-XL and PUMA in a TP53-dependent manner, and leads to cell cycle arrest[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bomedemstat hydrochloride Related Antibodies

Apoptosis Analysis[1]

Cell Line: SET-2 cells
Concentration: 50 nM, 100 nM, and 1 μM
Incubation Time: 96 hours
Result: Decreased levels of the antiapoptotic protein BCL-XL and increased levels of the pro-apoptotic protein PUMA.
In Vivo

Bomedemstat treatment (oral gavage; 45 mg/kg; once daily; 56 d) normalizes or improves blood cell counts, reduces spleen volumes, restores normal splenic architecture, and reduces bone marrow fibrosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mx-Jak2V617F mice[1]
Dosage: 45 mg/kg
Administration: Oral gavage; 45 mg/kg; once daily; 56 days
Result: Reduced splenomegaly significantly with a few treated mice normalizing their spleen weight, the 56-day course led to partial restoration of lymph follicles and spleen architecture by histological examination.
Clinical Trial
Molecular Weight

556.07

Formula

C28H35ClFN7O2
Appearance

Solid

Color

White to yellow

SMILES

O=C(N1CCN(CC1)C)[C@@H](NC(C2=CC=C(N3C=CN=N3)C=C2)=O)CCCN[C@H]4[C@@](C5=CC=C(C=C5)F)([H])C4.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 75 mg/mL (134.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7983 mL 8.9917 mL 17.9833 mL
5 mM 0.3597 mL 1.7983 mL 3.5967 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.94%

COA (247 KB) HNMR (225 KB) RP-HPLC (269 KB) LCMS (97 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7983 mL 8.9917 mL 17.9833 mL 44.9584 mL
5 mM 0.3597 mL 1.7983 mL 3.5967 mL 8.9917 mL
10 mM 0.1798 mL 0.8992 mL 1.7983 mL 4.4958 mL
15 mM 0.1199 mL 0.5994 mL 1.1989 mL 2.9972 mL
20 mM 0.0899 mL 0.4496 mL 0.8992 mL 2.2479 mL
25 mM 0.0719 mL 0.3597 mL 0.7193 mL 1.7983 mL
30 mM 0.0599 mL 0.2997 mL 0.5994 mL 1.4986 mL
40 mM 0.0450 mL 0.2248 mL 0.4496 mL 1.1240 mL
50 mM 0.0360 mL 0.1798 mL 0.3597 mL 0.8992 mL
60 mM 0.0300 mL 0.1499 mL 0.2997 mL 0.7493 mL
80 mM 0.0225 mL 0.1124 mL 0.2248 mL 0.5620 mL
100 mM 0.0180 mL 0.0899 mL 0.1798 mL 0.4496 mL
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Bomedemstat hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BomedemstatIMG-7289IMG7289IMG 7289Histone DemethylaseApoptosisoral activitylysine-specific demethylase 1anti-cancer activityanti-proliferationinduce apoptosisSET-2Inhibitorinhibitorinhibit

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