2. Stem Cell/Wnt
  3. Wnt
  4. Box5

Box5 is a potent Wnt5a antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca2+ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Box5 Chemical Structure

Box5 Chemical Structure

CAS No. : 1206604-29-6

Size Price Stock Quantity
5 mg USD 150 In-stock
10 mg USD 255 In-stock
50 mg   Get quote  
100 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

Other Forms of Box5:

Box5 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Box5 is a potent Wnt5a antagonist. Box5 inhibits Wnt5a signaling and inhibits Wnt5a-mediated Ca2+ release. Box5 inhibits cell migration. Box5 has the potential for the research of melanoma[1].

IC50 & Target

Wnt5a[1]
In Vitro

Box5 (100 μM) decreases the expression of rWnt5a (0.1 μg/mL) stimulated p-MARCKS in A2058 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Box5 Related Antibodies

Western Blot Analysis[1]

Cell Line: A2058 cells
Concentration: 100 μM
Incubation Time: Overnight
Result: Decreased the expression of rWnt5a (0.1 μg/mL) stimulated p-MARCKS.
Molecular Weight

766.88

Formula

C30H50N6O13S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

{t-Boc}-Met-Asp-Gly-Cys-Glu-Leu
Sequence Shortening

{t-Boc}-MDGCEL
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (130.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3040 mL 6.5199 mL 13.0399 mL
5 mM 0.2608 mL 1.3040 mL 2.6080 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.32%

SDS (251 KB)

COA (247 KB) RP-HPLC (133 KB) MS (199 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3040 mL 6.5199 mL 13.0398 mL 32.5996 mL
5 mM 0.2608 mL 1.3040 mL 2.6080 mL 6.5199 mL
10 mM 0.1304 mL 0.6520 mL 1.3040 mL 3.2600 mL
15 mM 0.0869 mL 0.4347 mL 0.8693 mL 2.1733 mL
20 mM 0.0652 mL 0.3260 mL 0.6520 mL 1.6300 mL
25 mM 0.0522 mL 0.2608 mL 0.5216 mL 1.3040 mL
30 mM 0.0435 mL 0.2173 mL 0.4347 mL 1.0867 mL
40 mM 0.0326 mL 0.1630 mL 0.3260 mL 0.8150 mL
50 mM 0.0261 mL 0.1304 mL 0.2608 mL 0.6520 mL
60 mM 0.0217 mL 0.1087 mL 0.2173 mL 0.5433 mL
80 mM 0.0163 mL 0.0815 mL 0.1630 mL 0.4075 mL
100 mM 0.0130 mL 0.0652 mL 0.1304 mL 0.3260 mL
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Box5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Box51206604-29-6Box 5Box-5WntA2058 cellsrWnt5amelanomaanti-metastaticInhibitorinhibitorinhibit

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