2. MAPK/ERK Pathway
  3. Raf
  4. Braftide

Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence.

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Braftide Chemical Structure

Braftide Chemical Structure

CAS No. : 2411851-64-2

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Braftide Related Antibodies

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Description

Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence[1].

Molecular Weight

1243.52

Formula

C57H94N16O13S
CAS No.
Sequence

Thr-Arg-His-Val-Asn-Ile-Leu-Leu-Phe-Met
Sequence Shortening

TRHVNILLFM
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Purity & Documentation
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Braftide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Braftide2411851-64-2RafRaf kinasesKRASHEK293FHCT-116HCT-15colon cancerInhibitorinhibitorinhibit

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