2. MAPK/ERK Pathway
  3. Raf
  4. Braftide

Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence.

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Braftide Chemical Structure

Braftide Chemical Structure

CAS No. : 2411851-64-2

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Based on 1 publication(s) in Google Scholar

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Description

Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAFG469A with IC50 of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC50 is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence[1].

Molecular Weight

1243.52

Formula

C57H94N16O13S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Thr-Arg-His-Val-Asn-Ile-Leu-Leu-Phe-Met
Sequence Shortening

TRHVNILLFM
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (80.42 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.8042 mL 4.0208 mL 8.0417 mL
5 mM 0.1608 mL 0.8042 mL 1.6083 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.8042 mL 4.0208 mL 8.0417 mL 20.1042 mL
5 mM 0.1608 mL 0.8042 mL 1.6083 mL 4.0208 mL
10 mM 0.0804 mL 0.4021 mL 0.8042 mL 2.0104 mL
15 mM 0.0536 mL 0.2681 mL 0.5361 mL 1.3403 mL
20 mM 0.0402 mL 0.2010 mL 0.4021 mL 1.0052 mL
25 mM 0.0322 mL 0.1608 mL 0.3217 mL 0.8042 mL
30 mM 0.0268 mL 0.1340 mL 0.2681 mL 0.6701 mL
40 mM 0.0201 mL 0.1005 mL 0.2010 mL 0.5026 mL
50 mM 0.0161 mL 0.0804 mL 0.1608 mL 0.4021 mL
60 mM 0.0134 mL 0.0670 mL 0.1340 mL 0.3351 mL
80 mM 0.0101 mL 0.0503 mL 0.1005 mL 0.2513 mL
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Braftide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Braftide2411851-64-2RafRaf kinasesKRASHEK293FHCT-116HCT-15colon cancerInhibitorinhibitorinhibit

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