2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. BRD32048

BRD32048 is a direct binder of ETV1 with a KD of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen.

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BRD32048 Chemical Structure

BRD32048 Chemical Structure

CAS No. : 433694-46-3

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Based on 1 publication(s) in Google Scholar

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Description

BRD32048 is a direct binder of ETV1 with a KD of 17.1 μM. BRD32048 modulates both ETV1-mediated transcriptional activity and invasion of ETV1-driven cancer cells. BRD32048 inhibits ETV1 acetylation and promotes its degradation. BRD32048 acts as a top candidate ETV1 perturbagen[1].

Molecular Weight

314.39

Formula

C16H22N6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

NC1=NC(CN2CCCCC2)=NC(NC3=CC=C(OC)C=C3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (397.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1808 mL 15.9038 mL 31.8076 mL
5 mM 0.6362 mL 3.1808 mL 6.3615 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1808 mL 15.9038 mL 31.8076 mL 79.5191 mL
5 mM 0.6362 mL 3.1808 mL 6.3615 mL 15.9038 mL
10 mM 0.3181 mL 1.5904 mL 3.1808 mL 7.9519 mL
15 mM 0.2121 mL 1.0603 mL 2.1205 mL 5.3013 mL
20 mM 0.1590 mL 0.7952 mL 1.5904 mL 3.9760 mL
25 mM 0.1272 mL 0.6362 mL 1.2723 mL 3.1808 mL
30 mM 0.1060 mL 0.5301 mL 1.0603 mL 2.6506 mL
40 mM 0.0795 mL 0.3976 mL 0.7952 mL 1.9880 mL
50 mM 0.0636 mL 0.3181 mL 0.6362 mL 1.5904 mL
60 mM 0.0530 mL 0.2651 mL 0.5301 mL 1.3253 mL
80 mM 0.0398 mL 0.1988 mL 0.3976 mL 0.9940 mL
100 mM 0.0318 mL 0.1590 mL 0.3181 mL 0.7952 mL
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BRD32048 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BRD32048433694-46-3BRD 32048BRD-32048DNA/RNA SynthesisETV1 direct bindertranscription factor,acetylationdegradationETV1 perturbagenInhibitorinhibitorinhibit

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