2. PROTAC
  3. PROTAC Linkers
  4. Bromo-PEG1-C2-azide

Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Bromo-PEG1-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

For research use only. We do not sell to patients.

Bromo-PEG1-C2-azide Chemical Structure

Bromo-PEG1-C2-azide Chemical Structure

CAS No. : 1144106-65-9

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5 mg USD 65 In-stock
10 mg USD 95 In-stock
25 mg USD 160 In-stock
50 mg USD 230 In-stock
100 mg USD 330 In-stock
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Based on 1 publication(s) in Google Scholar

Bromo-PEG1-C2-azide Related Antibodies

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Description

Bromo-PEG1-C2-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG1-C2-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Bromo-PEG1-C2-azide Related Antibodies
Molecular Weight

194.03

Formula

C4H8BrN3O
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

BrCCOCCN=[N+]=[N-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 350 mg/mL (1803.84 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.1538 mL 25.7692 mL 51.5384 mL
5 mM 1.0308 mL 5.1538 mL 10.3077 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.1538 mL 25.7692 mL 51.5384 mL 128.8461 mL
5 mM 1.0308 mL 5.1538 mL 10.3077 mL 25.7692 mL
10 mM 0.5154 mL 2.5769 mL 5.1538 mL 12.8846 mL
15 mM 0.3436 mL 1.7179 mL 3.4359 mL 8.5897 mL
20 mM 0.2577 mL 1.2885 mL 2.5769 mL 6.4423 mL
25 mM 0.2062 mL 1.0308 mL 2.0615 mL 5.1538 mL
30 mM 0.1718 mL 0.8590 mL 1.7179 mL 4.2949 mL
40 mM 0.1288 mL 0.6442 mL 1.2885 mL 3.2212 mL
50 mM 0.1031 mL 0.5154 mL 1.0308 mL 2.5769 mL
60 mM 0.0859 mL 0.4295 mL 0.8590 mL 2.1474 mL
80 mM 0.0644 mL 0.3221 mL 0.6442 mL 1.6106 mL
100 mM 0.0515 mL 0.2577 mL 0.5154 mL 1.2885 mL
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Bromo-PEG1-C2-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bromo-PEG1-C2-azide1144106-65-9PROTAC LinkersInhibitorinhibitorinhibit

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