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CaMKK2-IN-1 is a selective, ligand-efficient inhibitor of CaMKK2, with IC50 of 7 nM.

For research use only. We do not sell to patients.

CaMKK2-IN-1 Chemical Structure

CaMKK2-IN-1 Chemical Structure

CAS No. : 3032691-65-6

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5 mg USD 395 In-stock
10 mg USD 670 In-stock
25 mg USD 1410 In-stock
50 mg USD 2259 In-stock
100 mg USD 3615 In-stock
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Based on 1 publication(s) in Google Scholar

CaMKK2-IN-1 Related Antibodies

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Description

CaMKK2-IN-1 is a selective, ligand-efficient inhibitor of CaMKK2, with IC50 of 7 nM[1].

IC50 & Target

CaMKK2 (IC50 = 7 nM)[1]
Molecular Weight

362.42

Formula

C22H22N2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC1=CC=C(C(C2=CC(C3CCCC3)=C(C(O)=O)C=C2)=NC=N4)C4=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 40 mg/mL (110.37 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7592 mL 13.7961 mL 27.5923 mL
5 mM 0.5518 mL 2.7592 mL 5.5185 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 4 mg/mL (11.04 mM); Clear solution

    This protocol yields a clear solution of ≥ 4 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (40.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7592 mL 13.7961 mL 27.5923 mL 68.9807 mL
5 mM 0.5518 mL 2.7592 mL 5.5185 mL 13.7961 mL
10 mM 0.2759 mL 1.3796 mL 2.7592 mL 6.8981 mL
15 mM 0.1839 mL 0.9197 mL 1.8395 mL 4.5987 mL
20 mM 0.1380 mL 0.6898 mL 1.3796 mL 3.4490 mL
25 mM 0.1104 mL 0.5518 mL 1.1037 mL 2.7592 mL
30 mM 0.0920 mL 0.4599 mL 0.9197 mL 2.2994 mL
40 mM 0.0690 mL 0.3449 mL 0.6898 mL 1.7245 mL
50 mM 0.0552 mL 0.2759 mL 0.5518 mL 1.3796 mL
60 mM 0.0460 mL 0.2299 mL 0.4599 mL 1.1497 mL
80 mM 0.0345 mL 0.1725 mL 0.3449 mL 0.8623 mL
100 mM 0.0276 mL 0.1380 mL 0.2759 mL 0.6898 mL
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CaMKK2-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CaMKK2-IN-13032691-65-6OtherscancerTHP-1ligand-directed degradersInhibitorinhibitorinhibit

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