2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. Mineralocorticoid Receptor
  4. Canrenoate potassium

Canrenoate potassium  (Synonyms: Aldadiene potassium; SC-14266)

Cat. No.: HY-B1582A Purity: 99.89%
SDS COA Handling Instructions

Molarity Calculator

Canrenoate (Aldadiene) potassium, a proagent that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension.

For research use only. We do not sell to patients.

Canrenoate potassium Chemical Structure

Canrenoate potassium Chemical Structure

CAS No. : 2181-04-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 33 In-stock
Solution
10 mM * 1 mL in Water USD 33 In-stock
Solid
100 mg USD 30 In-stock
500 mg USD 50 In-stock
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5 g   Get quote  

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

Canrenoate potassium Related Antibodies

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Description

Canrenoate (Aldadiene) potassium, a proagent that releases canrenone, is a potent, competitive mineralocorticoid receptor (aldosterone receptor) antagonist. Potassium canrenoate, as a diuretic, is used for the research of hypertension[1][2][3].

In Vivo

Potassium canrenoate has been shown to cause in rats a dose-dependent increase in myelogenous leukemia and statistically significant increases in malignant tumor of the liver, thyroid, brain and mammary gland[2][3].
Potassium canrenoate (20 mg/kg/day; drinking water) reduces isoprenaline-induced cardiac fibrosis in the rat[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

396.56

Formula

C22H29KO4
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

C[C@@]12[C@@](CCC(O[K])=O)(O)CC[C@@]1([H])[C@]3([H])C=CC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (252.17 mM; ultrasonic and warming and heat to 60°C)

DMSO : 2 mg/mL (5.04 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5217 mL 12.6084 mL 25.2169 mL
5 mM 0.5043 mL 2.5217 mL 5.0434 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.89%

SDS (392 KB)

COA (250 KB) HNMR (266 KB) LCMS (95 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.5217 mL 12.6084 mL 25.2169 mL 63.0422 mL
5 mM 0.5043 mL 2.5217 mL 5.0434 mL 12.6084 mL
H2O 10 mM 0.2522 mL 1.2608 mL 2.5217 mL 6.3042 mL
15 mM 0.1681 mL 0.8406 mL 1.6811 mL 4.2028 mL
20 mM 0.1261 mL 0.6304 mL 1.2608 mL 3.1521 mL
25 mM 0.1009 mL 0.5043 mL 1.0087 mL 2.5217 mL
30 mM 0.0841 mL 0.4203 mL 0.8406 mL 2.1014 mL
40 mM 0.0630 mL 0.3152 mL 0.6304 mL 1.5761 mL
50 mM 0.0504 mL 0.2522 mL 0.5043 mL 1.2608 mL
60 mM 0.0420 mL 0.2101 mL 0.4203 mL 1.0507 mL
80 mM 0.0315 mL 0.1576 mL 0.3152 mL 0.7880 mL
100 mM 0.0252 mL 0.1261 mL 0.2522 mL 0.6304 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Canrenoate potassium Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Canrenoate2181-04-6Aldadiene SC-14266SC14266SC 14266SC-14266Mineralocorticoid ReceptorcompetitivediuretichypertensioncardiacfibrosisInhibitorinhibitorinhibit

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