Catechin 7-O-β-D-glucopyranoside

Cat. No.: HY-N10587 Purity: 99.48%: FAQs
Data Sheet SDS COA Handling Instructions

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Catechin 7-O-beta-D-glucopyranoside is an orally active natural product found in Ulmus davidiana and Paeonia obovata. Catechin 7-O-β-D-glucopyranoside shows antioxidant and anti-inflammatory activities, and attenuates mitochondrial dysfunction. Catechin 7-O-beta-D-glucopyranoside can be used in intestinal inflammatory disease research.

For research use only. We do not sell to patients.

Catechin 7-O-β-D-glucopyranoside Chemical Structure

CAS No. : 65597-47-9

Size	Price	Stock	Quantity
5 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 270	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Catechin 7-O-β-D-glucopyranoside (10 μg/mL; 24 h) shows protective effect against Streptozotocin-induced cell damage by its antioxidant effects and the attenuation of mitochondrial dysfunction^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[3]

Cell Line:	RINm5F rat pancreatic β-cells
Concentration:	10 μg/mL
Incubation Time:	24 hours
Result:	Increased the MnSOD level attenuated by Streptozotocin treatment. Restored the Streptozotocin-induced reduction in mitochondrial CAT level.

In Vivo

Catechin 7-O-β-D-glucopyranoside (intraperitoneal injection; 10 mg/kg; once) treatment shows mild protective effect against lethality induced by LPS/D-GalN^[1].
Catechin 7-O-β-D-glucopyranoside (oral administration; 10 mg/kg; once daily; 7 d) treatment prevents intestinal inflammatory damages in TNBS model of rat colitis^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Mice injected with LPS/D-GalN^[1]
Dosage:	10 mg/kg
Administration:	Intraperitoneal injection; 10 mg/kg; once
Result:	Showed 80% LPS/DGalN-induced lethality in mice.

Animal Model:	Rat model of trinitrobenzenesulfonic acid (TNBS)-induced colitis ^[2]
Dosage:	10 mg/kg
Administration:	Oral administration; 10 mg/kg; once daily; 7 days
Result:	Suppressed body weight loss and intestinal inflammatory damages in TNBS-induced colitic rats. Reduced myeloperoxidase activity and malondialdehyde level, but increased glutathione level in the TNBS colitic rats.

Molecular Weight

452.41

Formula

C₂₁H₂₄O₁₁

CAS No.

65597-47-9

Appearance

Solid

Color

White to off-white

SMILES

OC1=C2C(O[C@H](C3=CC(O)=C(C=C3)O)[C@H](C2)O)=CC(O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4O)O)O)CO)=C1

Structure Classification

Phenols

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (276.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2104 mL	11.0519 mL	22.1038 mL
5 mM	0.4421 mL	2.2104 mL	4.4208 mL
10 mM	0.2210 mL	1.1052 mL	2.2104 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.48%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (250 KB) HNMR (329 KB) CNMR (352 KB) RP-HPLC (207 KB) MS (122 KB)

Handling Instructions (2659 KB)

References

[1]. Zheng MS, et al. Protective constituents against sepsis in mice from the root barks of Ulmus davidiana var. japonica. Arch Pharm Res. 2011 Sep;34(9):1443-50. [Content Brief]

[2]. Kook SH, et al. Catechin-7-O-β-D-glucopyranoside isolated from the seed of Phaseolus calcaratus Roxburgh ameliorates experimental colitis in rats. Int Immunopharmacol. 2015 Dec;29(2):521-527. [Content Brief]

[3]. Kim KC, et al. Cytoprotective effects of catechin 7-O-β-D glucopyranoside against mitochondrial dysfunction damaged by streptozotocin in RINm5F cells. Cell Biochem Funct. 2010 Dec 2;28(8):651-60. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2104 mL	11.0519 mL	22.1038 mL	55.2596 mL
	5 mM	0.4421 mL	2.2104 mL	4.4208 mL	11.0519 mL
	10 mM	0.2210 mL	1.1052 mL	2.2104 mL	5.5260 mL
	15 mM	0.1474 mL	0.7368 mL	1.4736 mL	3.6840 mL
	20 mM	0.1105 mL	0.5526 mL	1.1052 mL	2.7630 mL
	25 mM	0.0884 mL	0.4421 mL	0.8842 mL	2.2104 mL
	30 mM	0.0737 mL	0.3684 mL	0.7368 mL	1.8420 mL
	40 mM	0.0553 mL	0.2763 mL	0.5526 mL	1.3815 mL
	50 mM	0.0442 mL	0.2210 mL	0.4421 mL	1.1052 mL
	60 mM	0.0368 mL	0.1842 mL	0.3684 mL	0.9210 mL
	80 mM	0.0276 mL	0.1381 mL	0.2763 mL	0.6907 mL
	100 mM	0.0221 mL	0.1105 mL	0.2210 mL	0.5526 mL