2. Immunology/Inflammation Metabolic Enzyme/Protease Neuronal Signaling Stem Cell/Wnt NF-κB Anti-infection
  3. COX Lipoxygenase Notch Reactive Oxygen Species Bacterial
  4. Psoralidin

Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation.

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Psoralidin Chemical Structure

Psoralidin Chemical Structure

CAS No. : 18642-23-4

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10 mM * 1 mL in DMSO
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Based on 5 publication(s) in Google Scholar

Other Forms of Psoralidin:

Psoralidin Related Antibodies

Top Publications Citing Use of Products

    Psoralidin purchased from MedChemExpress. Usage Cited in: Chin Med. 2023 Mar 31;18(1):34.  [Abstract]

    Psoralidin (20, 30, 40 µM; 24 h) significantly reduces the expression of the Snail, MMP2 and MMP9 in OS cells.

    View All COX Isoform Specific Products:

    View All Isoforms
    COX COX-1 COX-2 COX-3

    View All Lipoxygenase Isoform Specific Products:

    View All Isoforms
    5-LOX 12-LOX 15-LOX

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Psoralidin is a dual inhibitor of COX-2 and 5-LOX, regulates ionizing radiation (IR)-induced pulmonary inflammation.Anti-cancer, anti-bacterial, and anti-inflammatory properties[1]. Psoralidin significantly downregulates NOTCH1 signaling. Psoralidin also greatly induces ROS generation[2].

    IC50 & Target[1]

    COX-2

     

    5-LOX

     

    In Vitro

    Three breast cancer cell (BCC)populations (ALDH- cells, ALDH+ cells, and commercial BSCSs) are sensitive to Psoralidin treatment (10, 15, 20, and 25 μM; 24 hours) with IC50s ranging from 18 to 21 μM; however, the MCF-12A cells were resistant to Psoralidin[2].
    Psoralidin (30 μM; 24 hours) results in a significant induction of apoptosis for ALDH- cells, ALDH+ cells, and commercial BCSCs[2].
    Psoralidin treatment also downregulates NOTCH1 expression in both ALDH- and ALDH+ cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Psoralidin Related Antibodies

    Cell Viability Assay[2]

    Cell Line: ALDH- cells, ALDH+ cells, commercial breast cancer stem cells (BSCSs), and normal breast epithelial cells (MCF-12A)
    Concentration: 10, 15, 50, and 25 μM
    Incubation Time: 24 hours
    Result: IC50s of 18 to 21 μM for ALDH- cells, ALDH+ cells, commercial BCSCs.

    Apoptosis Analysis[2]

    Cell Line: ALDH- cells, ALDH+ cells, and commercial BCSCs
    Concentration: 20 and 30 μM
    Incubation Time: 24 hours
    Result: No significant induction of apoptosis was observed for any of the three cell types following treatment at 20 μM. However, 53.60%, 44.1%, and 45.9% of cells were apoptotic at 30 μMin ALDH- cells, ALDH+ cells, and commercial BCSCs, respectively.
    In Vivo

    Psoralidin (5 mg/kg) regulates expression of pro-inflammatory cytokines that play an important role in inflammatory diseasesin IR-irradiated lung of BALB/c mouse[1].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: BALB/c mice[1]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal application; 30 min before and 1 h after IR irradiation (20 Gy).
    Result: Anti-inflammatory effect in IR-irradiated mice.
    Molecular Weight

    336.34

    Formula

    C20H16O5
    CAS No.
    Appearance

    Solid

    Color

    White to off-white

    SMILES

    C/C(C)=C\CC1=C(C=C2OC(C3=C(C2=C1)OC4=C3C=CC(O)=C4)=O)O
    Structure Classification
    Initial Source
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 50 mg/mL (148.66 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.9732 mL 14.8659 mL 29.7318 mL
    5 mM 0.5946 mL 2.9732 mL 5.9464 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo:

    Select the appropriate dissolution method based on your experimental animal and administration route.

    For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
    To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
    The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

    • Protocol 1

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

      Solubility: 2.08 mg/mL (6.18 mM); Suspended solution; Need ultrasonic

      This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

      Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
    • Protocol 2

      Add each solvent one by one:  10% DMSO    90% Corn Oil

      Solubility: ≥ 2.08 mg/mL (6.18 mM); Clear solution

      This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

      Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    Dosing volume
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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Please enter your animal formula composition:
    %
    DMSO +
    % 
    +
    %
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    Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
    The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
    Calculation results:
    Working solution concentration: mg/mL
    Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
    Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
     If the continuous dosing period exceeds half a month, please choose this protocol carefully.
    Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
    Purity & Documentation

    Purity: 99.90%

    SDS (393 KB)

    COA (253 KB) HNMR (244 KB) RP-HPLC (220 KB) MS (265 KB)

    Handling Instructions (2659 KB)
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.9732 mL 14.8659 mL 29.7318 mL 74.3295 mL
    5 mM 0.5946 mL 2.9732 mL 5.9464 mL 14.8659 mL
    10 mM 0.2973 mL 1.4866 mL 2.9732 mL 7.4330 mL
    15 mM 0.1982 mL 0.9911 mL 1.9821 mL 4.9553 mL
    20 mM 0.1487 mL 0.7433 mL 1.4866 mL 3.7165 mL
    25 mM 0.1189 mL 0.5946 mL 1.1893 mL 2.9732 mL
    30 mM 0.0991 mL 0.4955 mL 0.9911 mL 2.4777 mL
    40 mM 0.0743 mL 0.3716 mL 0.7433 mL 1.8582 mL
    50 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4866 mL
    60 mM 0.0496 mL 0.2478 mL 0.4955 mL 1.2388 mL
    80 mM 0.0372 mL 0.1858 mL 0.3716 mL 0.9291 mL
    100 mM 0.0297 mL 0.1487 mL 0.2973 mL 0.7433 mL
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    Psoralidin Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Psoralidin18642-23-4COXLipoxygenaseNotchReactive Oxygen SpeciesBacterialCyclooxygenaseLOXIonizingradiationIRCOX-25-LOXAnti-inflammationNOTCH1reactiveoxygenspeciesROSInhibitorinhibitorinhibit

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