Cauloside A (Synonyms: Leontoside A)

Cat. No.: HY-N3557 Purity: 99.55%: FAQs
Data Sheet SDS COA Handling Instructions

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Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A has potent antifungal activity.

For research use only. We do not sell to patients.

Cauloside A Chemical Structure

CAS No. : 17184-21-3

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 600	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Cauloside A (Leontoside A) is a saponin isolated from Dipsacus asper roots. Cauloside A has potent antifungal activity^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	29.71 μM Compound: 10a	Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
A549	IC₅₀	40 μM Compound: 23	Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence Cell membrane permeabilization in human A549 cells assessed as drug level causing decrease in calcein fluorescence	[PMID: 19200744]
A549	IC₅₀	58 μM Compound: 23	Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction test	[PMID: 19200744]
DLD-1	IC₅₀	54 μM Compound: 23	Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence Cell membrane permeabilization in human DLD1 cells assessed as drug level causing decrease in calcein fluorescence	[PMID: 19200744]
DLD-1	IC₅₀	57 μM Compound: 23	Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction test	[PMID: 19200744]
HeLa	IC₅₀	27.67 μM Compound: 10a	Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
HepG2	IC₅₀	19.12 μM Compound: 10a	Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
HL-60	IC₅₀	14.52 μM Compound: 10a	Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]
RAW264.7	IC₅₀	2.25 μM Compound: 14	Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced nitirc oxide production preincubated for 1 hr followed by LPS-stimulation and measured after 18 hrs by Griess assay	[PMID: 31301930]
U-87MG ATCC	IC₅₀	18.45 μM Compound: 10a	Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay Cytotoxicity against human U87MG cells assessed as cell viability after 72 hrs by MTT assay	[PMID: 23992864]

Molecular Weight

604.81

Formula

C₃₅H₅₆O₈

CAS No.

17184-21-3

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]1(CC[C@@]2([H])[C@]3(C)CO)[C@@](CC=C([C@]4([H])CC5(C)C)[C@]1(CC[C@]4(CC5)C(O)=O)C)([H])[C@]2(CC[C@@H]3O[C@H](OC[C@@H]6O)[C@@H]([C@H]6O)O)C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (165.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6534 mL	8.2671 mL	16.5341 mL
5 mM	0.3307 mL	1.6534 mL	3.3068 mL
10 mM	0.1653 mL	0.8267 mL	1.6534 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.55%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (251 KB) HNMR (134 KB) CNMR (139 KB) RP-HPLC (210 KB) MS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Nam Hee Choi, et al. Antifungal activity of sterols and dipsacus saponins isolated from Dipsacus asper roots against phytopathogenic fungi. Pestic Biochem Physiol. 2017 Sep;141:103-108. [Content Brief]

[2]. Sandipan Datta, et al. Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential. J Nat Prod. 2014 Jan 24;77(1):111-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6534 mL	8.2671 mL	16.5341 mL	41.3353 mL
	5 mM	0.3307 mL	1.6534 mL	3.3068 mL	8.2671 mL
	10 mM	0.1653 mL	0.8267 mL	1.6534 mL	4.1335 mL
	15 mM	0.1102 mL	0.5511 mL	1.1023 mL	2.7557 mL
	20 mM	0.0827 mL	0.4134 mL	0.8267 mL	2.0668 mL
	25 mM	0.0661 mL	0.3307 mL	0.6614 mL	1.6534 mL
	30 mM	0.0551 mL	0.2756 mL	0.5511 mL	1.3778 mL
	40 mM	0.0413 mL	0.2067 mL	0.4134 mL	1.0334 mL
	50 mM	0.0331 mL	0.1653 mL	0.3307 mL	0.8267 mL
	60 mM	0.0276 mL	0.1378 mL	0.2756 mL	0.6889 mL
	80 mM	0.0207 mL	0.1033 mL	0.2067 mL	0.5167 mL
	100 mM	0.0165 mL	0.0827 mL	0.1653 mL	0.4134 mL

Cauloside A Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cauloside A17184-21-3Leontoside AFungalInhibitorinhibitorinhibit

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Cauloside A (Synonyms: Leontoside A)

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