2. Apoptosis
  3. Bcl-2 Family
  4. CBI1 formic

CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex.

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CBI1 formic Chemical Structure

CBI1 formic Chemical Structure

Size Price Stock Quantity
5 mg USD 380 In-stock
10 mg USD 610 In-stock
25 mg USD 1220 In-stock
50 mg USD 1950 In-stock
100 mg USD 3100 In-stock
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Other Forms of CBI1 formic:

CBI1 formic Related Antibodies

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Description

CBI1 formic is a covalent BAX inhibitor. CBI1 formic selectively derivatizes BAX at C126 and inhibits BAX activation by triggering ligands or point mutagenesis. CBI1 formic blocks t-2-hex lipidation and oligomerization of BAX. CBI1 formic inhibits BAX activation induced by BH3 ligands, F116A mutagenesis or t-2-hex[1].

Molecular Weight

461.40

Formula

C16H21BrN4O3S2
Appearance

Solid

SMILES

BrC1=CC=C(C2=NNC(C(NCCCSSCCN)=O)=C2)C=C1.OC=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (270.91 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1673 mL 10.8366 mL 21.6732 mL
5 mM 0.4335 mL 2.1673 mL 4.3346 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1673 mL 10.8366 mL 21.6732 mL 54.1829 mL
5 mM 0.4335 mL 2.1673 mL 4.3346 mL 10.8366 mL
10 mM 0.2167 mL 1.0837 mL 2.1673 mL 5.4183 mL
15 mM 0.1445 mL 0.7224 mL 1.4449 mL 3.6122 mL
20 mM 0.1084 mL 0.5418 mL 1.0837 mL 2.7091 mL
25 mM 0.0867 mL 0.4335 mL 0.8669 mL 2.1673 mL
30 mM 0.0722 mL 0.3612 mL 0.7224 mL 1.8061 mL
40 mM 0.0542 mL 0.2709 mL 0.5418 mL 1.3546 mL
50 mM 0.0433 mL 0.2167 mL 0.4335 mL 1.0837 mL
60 mM 0.0361 mL 0.1806 mL 0.3612 mL 0.9030 mL
80 mM 0.0271 mL 0.1355 mL 0.2709 mL 0.6773 mL
100 mM 0.0217 mL 0.1084 mL 0.2167 mL 0.5418 mL
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CBI1 formic Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CBI1CBI 1CBI-1Bcl-2 FamilyInhibitorinhibitorinhibit

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