2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. CCT129957

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM.

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CCT129957 Chemical Structure

CCT129957 Chemical Structure

CAS No. : 883098-58-6

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Based on 1 publication(s) in Google Scholar

CCT129957 Related Antibodies

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Description

CCT129957 is an indole derivative and a potent phospholipase C-γ (PLC-γ) inhibitor with an IC50 of ~3 μM and a GC50 of 15 μM. CCT129957 inhibits Ca2+ release in squamous carcinoma cells at ~15 μM[1][2].

IC50 & Target

IC50: ~3 μM (Phospholipase C-γ (PLC-γ))[1]
Cellular Effect
Cell Line Type Value Description References
Sf9 IC50
1 μM
Compound: CCT-129957
Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemical assay
Inhibition of recombinant phospholipase C gamma2 expressed in baculovirus infected Sf9 cells using [3H]PIP2 by flashplate biochemical assay
[PMID: 19303309]
In Vitro

The phenyl group on the left side sat in a lipophilic pocket formed of various amino acids. The predicted binding mode of CCT129957 displays a robust hydrogen bond pattern as well as a lipophilic contact[1].
CCT129957 inhibits the cell growth of renal UO-31 and the breast T-47D cancer cell lines by ~60-70%[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CCT129957 Related Antibodies
Molecular Weight

309.32

Formula

C17H15N3O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(N1)=CC2=C1C([N+]([O-])=O)=CC=C2)NCCC3=CC=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (323.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2329 mL 16.1645 mL 32.3290 mL
5 mM 0.6466 mL 3.2329 mL 6.4658 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2329 mL 16.1645 mL 32.3290 mL 80.8224 mL
5 mM 0.6466 mL 3.2329 mL 6.4658 mL 16.1645 mL
10 mM 0.3233 mL 1.6164 mL 3.2329 mL 8.0822 mL
15 mM 0.2155 mL 1.0776 mL 2.1553 mL 5.3882 mL
20 mM 0.1616 mL 0.8082 mL 1.6164 mL 4.0411 mL
25 mM 0.1293 mL 0.6466 mL 1.2932 mL 3.2329 mL
30 mM 0.1078 mL 0.5388 mL 1.0776 mL 2.6941 mL
40 mM 0.0808 mL 0.4041 mL 0.8082 mL 2.0206 mL
50 mM 0.0647 mL 0.3233 mL 0.6466 mL 1.6164 mL
60 mM 0.0539 mL 0.2694 mL 0.5388 mL 1.3470 mL
80 mM 0.0404 mL 0.2021 mL 0.4041 mL 1.0103 mL
100 mM 0.0323 mL 0.1616 mL 0.3233 mL 0.8082 mL
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CCT129957 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CCT129957883098-58-6CCT 129957CCT-129957PhospholipasePLC-γindoleGlu341Lys438Arg549IndoraminCa2+releaseInhibitorinhibitorinhibit

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