CDK1-IN-2

Name: CDK1-IN-2
Brand: MedChemExpress
SKU: HY-112463
Rating: 4.5 (1 reviews)

Cat. No.: HY-112463 Purity: 97.17%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

CDK1-IN-2 is a CDK1 inhibitor (IC₅₀: 5.8 μM).

For research use only. We do not sell to patients.

CDK1-IN-2 Chemical Structure

CAS No. : 220749-41-7

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

CDK1-IN-2 is a CDK1 inhibitor (IC₅₀: 5.8 μM)^[1].

IC₅₀ & Target^[1]

CDK1

5.8 μM (IC₅₀)

Cellular Effect

Cell Line	Type	Value	Description	References
Sf9	IC₅₀	> 20 μM Compound: Fig.3B, R3C1	Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrate Inhibition of GST-tagged AURORA A (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrate	[PMID: 30234987]
Sf9	IC₅₀	> 20 μM Compound: Fig.3B, R3C1	Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay Inhibition of GST-tagged CDK4/cyclin D1 (unknown origin) expressed in Baculovirus infected Sf9 cells using RPPTLSPIPHIPR peptide as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay	[PMID: 30234987]
Sf9	IC₅₀	> 20 μM Compound: Fig.3B, R3C1	Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay Inhibition of GST-tagged CDK9/CyclinT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay	[PMID: 30234987]
Sf9	IC₅₀	15.6 μM Compound: Fig.3B, R3C1	Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrate Inhibition of GST-tagged AURORA B (unknown origin) expressed in baculovirus infected Sf9 cells using MBP as substrate	[PMID: 30234987]
Sf9	IC₅₀	16 μM Compound: Fig.3B, R3C1	Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay Inhibition of GST-tagged CDK7/cyclinH/MAT1 (unknown origin) expressed in Baculovirus infected Sf9 cells using YSPTSPS-2 KK peptide as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay	[PMID: 30234987]
Sf9	IC₅₀	5.8 μM Compound: Fig.3B, R3C1	Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay Inhibition of GST-tagged CDK5/p25 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay	[PMID: 30234987]
Sf9	IC₅₀	6.7 μM Compound: Fig.3B, R3C1	Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay Inhibition of His-tagged CDK1/cyclin B1 (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay	[PMID: 30234987]
Sf9	IC₅₀	9.4 μM Compound: Fig.3B, R3C1	Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gamma-33P]-ATP by radiometric filter binding assay	[PMID: 30234987]

In Vitro

CDK1-IN-2 (“CDK1 inhibitor 1”, 0-19.8 μM, 24 h) arrests HCT-116 cells in G2/M phase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

294.74

Formula

C₁₇H₁₁ClN₂O

CAS No.

220749-41-7

Appearance

Solid

Color

White to yellow

SMILES

O=C1NC2=C(C=CC=C2)/C1=C\C3=C(Cl)NC4=C3C=CC=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 250 mg/mL (848.21 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.3928 mL	16.9641 mL	33.9282 mL
5 mM	0.6786 mL	3.3928 mL	6.7856 mL
10 mM	0.3393 mL	1.6964 mL	3.3928 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.17%

Select Batch:

Data Sheet (278 KB) SDS (251 KB)

COA (257 KB) HNMR (429 KB) LCMS (274 KB)

Handling Instructions (2659 KB)

References

[1]. Jorda R, et al. How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases? J Med Chem. 2018 Oct 25;61(20):9105-9120. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.3928 mL	16.9641 mL	33.9282 mL	84.8205 mL
	5 mM	0.6786 mL	3.3928 mL	6.7856 mL	16.9641 mL
	10 mM	0.3393 mL	1.6964 mL	3.3928 mL	8.4821 mL
	15 mM	0.2262 mL	1.1309 mL	2.2619 mL	5.6547 mL
	20 mM	0.1696 mL	0.8482 mL	1.6964 mL	4.2410 mL
	25 mM	0.1357 mL	0.6786 mL	1.3571 mL	3.3928 mL
	30 mM	0.1131 mL	0.5655 mL	1.1309 mL	2.8274 mL
	40 mM	0.0848 mL	0.4241 mL	0.8482 mL	2.1205 mL
	50 mM	0.0679 mL	0.3393 mL	0.6786 mL	1.6964 mL
	60 mM	0.0565 mL	0.2827 mL	0.5655 mL	1.4137 mL
	80 mM	0.0424 mL	0.2121 mL	0.4241 mL	1.0603 mL
	100 mM	0.0339 mL	0.1696 mL	0.3393 mL	0.8482 mL

CDK1-IN-2 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK1-IN-2220749-41-7CDKCyclin dependent kinaseHCT-116 cellscancerInhibitorinhibitorinhibit

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CDK1-IN-2

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CDK1-IN-2 Related Antibodies

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•Related Screening Libraries:

•Related Small Molecules:

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View All CDK Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

CDK1-IN-2 Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

CDK1-IN-2 Related Classifications

Keywords:

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