2. Anti-infection
  3. Bacterial Antibiotic
  4. Cefcapene pivoxil hydrochloride hydrate

Cefcapene pivoxil hydrochloride hydrate 

Cat. No.: HY-W040022 Purity: 99.41%
COA Handling Instructions

Molarity Calculator

Cefcapene pivoxil hydrochloride hydrate, the pivalate ester prodrug form of Cefcapene, is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride hydrate has the potential for the palmoplantar pustulosis (PPP) research.

For research use only. We do not sell to patients.

Cefcapene pivoxil hydrochloride hydrate Chemical Structure

Cefcapene pivoxil hydrochloride hydrate Chemical Structure

CAS No. : 147816-24-8

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cefcapene pivoxil hydrochloride hydrate:

Cefcapene pivoxil hydrochloride hydrate Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Cefcapene pivoxil hydrochloride hydrate, the pivalate ester prodrug form of Cefcapene, is an orally active third-generation cephalosporin with a wide spectrum of anti-bacterial activity. Cefcapene pivoxil hydrochloride hydrate has the potential for the palmoplantar pustulosis (PPP) research[1][2].

IC50 & Target

β-lactam

 

In Vivo

Cefcapene pivoxil hydrochloride hydrate (oral administration; 100mg/kg; 4 days) is effective against invasive BLNAR strains in mice lung, it stimates peak antibiotic concentrations of 1 to 2 μg/ml in the blood of mice from 30 to 120 min after intragastric administration[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old female C57BL/6J mice with bacterial suspension in BSG (1×109 CFU)[3]
Dosage: 100 mg/kg
Administration: Oral administration; 100mg/kg; 4 days
Result: Was against H. influenzae colonization in mouse lung.
Molecular Weight

622.11

Formula

C23H32ClN5O9S2
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

[H]Cl.O=C1N([C@@]([H])([C@@H]1NC(/C(C2=CSC(N)=N2)=C\CC)=O)SC3)C(C(OCOC(C(C)(C)C)=O)=O)=C3COC(N)=O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (200.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6074 mL 8.0372 mL 16.0743 mL
5 mM 0.3215 mL 1.6074 mL 3.2149 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (3.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*The compound is unstable in solutions, freshly prepared is recommended.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.41%

COA (254 KB) LCMS (94 KB) Elemental Analysis Report (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.6074 mL 8.0372 mL 16.0743 mL 40.1858 mL
5 mM 0.3215 mL 1.6074 mL 3.2149 mL 8.0372 mL
10 mM 0.1607 mL 0.8037 mL 1.6074 mL 4.0186 mL
15 mM 0.1072 mL 0.5358 mL 1.0716 mL 2.6791 mL
20 mM 0.0804 mL 0.4019 mL 0.8037 mL 2.0093 mL
25 mM 0.0643 mL 0.3215 mL 0.6430 mL 1.6074 mL
30 mM 0.0536 mL 0.2679 mL 0.5358 mL 1.3395 mL
40 mM 0.0402 mL 0.2009 mL 0.4019 mL 1.0046 mL
50 mM 0.0321 mL 0.1607 mL 0.3215 mL 0.8037 mL
60 mM 0.0268 mL 0.1340 mL 0.2679 mL 0.6698 mL
80 mM 0.0201 mL 0.1005 mL 0.2009 mL 0.5023 mL
100 mM 0.0161 mL 0.0804 mL 0.1607 mL 0.4019 mL
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Cefcapene pivoxil hydrochloride hydrate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefcapene pivoxil hydrochloride147816-24-8BacterialAntibioticPalmoplantar PustulosisArthro-OsteitisinfectiousPPPdiseaselymphangitislymphadenitischronic pyodermatonsillitis,?antibioticCFPN-PI；乐研下架（MCE上线）-陈委20200702Inhibitorinhibitorinhibit

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