Cefquinome sulfate

Name: Cefquinome sulfate
Brand: MedChemExpress
SKU: HY-N6665
Rating: 4.5 (1 reviews)

Cat. No.: HY-N6665 Purity: 98.63%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cefquinome sulfate is a cephem antibiotic, which inhibits members of the Enterobacteriaceae.

For research use only. We do not sell to patients.

Cefquinome sulfate Chemical Structure

CAS No. : 118443-89-3

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Free Sample (0.1 - 0.5 mg)		Apply Now
50 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Cefquinome sulfate:

Cefquinome Get quote
Cefquinome sulfate (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cefquinome sulfate is a cephem antibiotic, which inhibits members of the Enterobacteriaceae^[1].

IC₅₀ & Target

β-lactam

Molecular Weight

626.68

Formula

C₂₃H₂₆N₆O₉S₃

CAS No.

118443-89-3

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1[C@@H](NC(/C(C2=CSC(N)=N2)=N\OC)=O)[C@@]3([H])SCC(C[N+]4=C5CCCCC5=CC=C4)=C(C(O)=O)N13.O=S(O)([O-])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (199.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 2 mg/mL (3.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5957 mL	7.9786 mL	15.9571 mL
5 mM	0.3191 mL	1.5957 mL	3.1914 mL
10 mM	0.1596 mL	0.7979 mL	1.5957 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (3.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (3.32 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.63%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (253 KB) RP-HPLC (264 KB) MS (69 KB)

Handling Instructions (2659 KB)

References

[1]. Chin NX, et al. In vitro activity of cefquinome, a new cephalosporin, compared with other cephalosporin antibiotics. Diagn Microbiol Infect Dis. 1992 May-Jun;15(4):331-7. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	1.5957 mL	7.9786 mL	15.9571 mL	39.8928 mL
DMSO	5 mM	0.3191 mL	1.5957 mL	3.1914 mL	7.9786 mL
	10 mM	0.1596 mL	0.7979 mL	1.5957 mL	3.9893 mL
	15 mM	0.1064 mL	0.5319 mL	1.0638 mL	2.6595 mL
	20 mM	0.0798 mL	0.3989 mL	0.7979 mL	1.9946 mL
	25 mM	0.0638 mL	0.3191 mL	0.6383 mL	1.5957 mL
	30 mM	0.0532 mL	0.2660 mL	0.5319 mL	1.3298 mL
	40 mM	0.0399 mL	0.1995 mL	0.3989 mL	0.9973 mL
	50 mM	0.0319 mL	0.1596 mL	0.3191 mL	0.7979 mL
	60 mM	0.0266 mL	0.1330 mL	0.2660 mL	0.6649 mL
	80 mM	0.0199 mL	0.0997 mL	0.1995 mL	0.4987 mL
	100 mM	0.0160 mL	0.0798 mL	0.1596 mL	0.3989 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.