CGP 12177 hydrochloride (Synonyms: (±)-CGP 12177 hydrochloride)

Cat. No.: HY-101393A Purity: 99.69%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CGP 12177 ((±)-CGP 12177) hydrochloride is a β Adrenergic Receptor Ligand. CGP 12177 hydrochloride is a high affinity antagonist of β1- and β2-AR. CGP 12177 hydrochloride is also shown to interact, with a lower affinity, with the β3-AR and to exhibit a partial agonist activity on rodent and human β3-AR. CGP 12177 hydrochloride exhibits partial agonist properties for α1-AR in rat pulmonary artery.

For research use only. We do not sell to patients.

CGP 12177 hydrochloride Chemical Structure

CAS No. : 64208-32-8

Size	Price	Stock	Quantity
5 mg	USD 159	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 254	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Beta-1 adrenergic receptor

Beta-2 adrenergic receptor

Beta-3 adrenergic receptor

α1-adrenergic receptor

Molecular Weight

315.80

Formula

C₁₄H₂₂ClN₃O₃

CAS No.

64208-32-8

Appearance

Solid

Color

White to off-white

SMILES

O=C1NC2=C(OCC(O)CNC(C)(C)C)C=CC=C2N1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 10 mg/mL (31.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.1666 mL	15.8328 mL	31.6656 mL
5 mM	0.6333 mL	3.1666 mL	6.3331 mL
10 mM	0.3167 mL	1.5833 mL	3.1666 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.69%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (252 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Leblais V, et al. Role of alpha-adrenergic receptors in the effect of the beta-adrenergic receptor ligands, CGP 12177, bupranolol, and SR 59230A, on the contraction of rat intrapulmonary artery. J Pharmacol Exp Ther. 2004 Apr;309(1):137-45. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.1666 mL	15.8328 mL	31.6656 mL	79.1640 mL
	5 mM	0.6333 mL	3.1666 mL	6.3331 mL	15.8328 mL
	10 mM	0.3167 mL	1.5833 mL	3.1666 mL	7.9164 mL
	15 mM	0.2111 mL	1.0555 mL	2.1110 mL	5.2776 mL
	20 mM	0.1583 mL	0.7916 mL	1.5833 mL	3.9582 mL
	25 mM	0.1267 mL	0.6333 mL	1.2666 mL	3.1666 mL
	30 mM	0.1056 mL	0.5278 mL	1.0555 mL	2.6388 mL

CGP 12177 hydrochloride Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGP 1217764208-32-8(±)-CGP 12177CGP12177CGP-12177Adrenergic ReceptorBeta ReceptorIntrapulmonary ArteryInhibitorinhibitorinhibit

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