CGP 20712 dihydrochloride

Cat. No.: HY-101355A Purity: 99.4%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC₅₀ of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors.

For research use only. We do not sell to patients.

CGP 20712 dihydrochloride Chemical Structure

CAS No. : 1216905-73-5

Size	Price	Stock	Quantity
1 mg	USD 170	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 424	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 679	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of CGP 20712 dihydrochloride:

CGP 20712 Get quote
CGP 20712 A Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

CGP 20712 dihydrochloride is a highly selective β1-adrenoceptor antagonist with an IC₅₀ of 0.7 nM. CGP 20712 dihydrochloride exhibits ~10,000-fold selectivity over β2-adrenoceptors^[1].

Molecular Weight

567.39

Formula

C₂₃H₂₇Cl₂F₃N₄O₅

CAS No.

1216905-73-5

Appearance

Solid

Color

White to light yellow

SMILES

O=C(N)C1=CC(OCCNCC(O)COC2=CC=C(C3=NC(C(F)(F)F)=CN3C)C=C2)=CC=C1O.Cl.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 28 mg/mL (49.35 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7625 mL	8.8123 mL	17.6246 mL
5 mM	0.3525 mL	1.7625 mL	3.5249 mL
10 mM	0.1762 mL	0.8812 mL	1.7625 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.4%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (246 KB) Elemental Analysis Report (103 KB)

Handling Instructions (2659 KB)

References

[1]. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. [Content Brief]

[2]. Dooley DJ, et al. CGP 20712 A: a useful tool for quantitating beta 1- and beta 2-adrenoceptors. Eur J Pharmacol. 1986 Oct 14;130(1-2):137-9. [Content Brief]

[3]. Kitagawa Y, et al. Determination of beta-adrenoceptor subtype on rat isolated ventricular myocytes by use of highly selective beta-antagonists. Br J Pharmacol. 1995 Sep;116(1):1635-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7625 mL	8.8123 mL	17.6246 mL	44.0614 mL
	5 mM	0.3525 mL	1.7625 mL	3.5249 mL	8.8123 mL
	10 mM	0.1762 mL	0.8812 mL	1.7625 mL	4.4061 mL
	15 mM	0.1175 mL	0.5875 mL	1.1750 mL	2.9374 mL
	20 mM	0.0881 mL	0.4406 mL	0.8812 mL	2.2031 mL
	25 mM	0.0705 mL	0.3525 mL	0.7050 mL	1.7625 mL
	30 mM	0.0587 mL	0.2937 mL	0.5875 mL	1.4687 mL
	40 mM	0.0441 mL	0.2203 mL	0.4406 mL	1.1015 mL