2. Metabolic Enzyme/Protease
  3. Lactate Dehydrogenase
  4. CHK-336

CHK-336 (Example 1) is an orally active LDHA inhibitor (IC50<1 nM) that inhibits lactate production in mouse hepatocytes. CHK-336 can be used in the study of hyperoxaluria.

For research use only. We do not sell to patients.

CHK-336 Chemical Structure

CHK-336 Chemical Structure

CAS No. : 2743436-86-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 508 In-stock
Solution
10 mM * 1 mL in DMSO USD 508 In-stock
Solid
5 mg USD 435 In-stock
10 mg USD 700 In-stock
25 mg USD 1400 In-stock
50 mg USD 2250 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

CHK-336 Related Antibodies

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Description

CHK-336 (Example 1) is an orally active LDHA inhibitor (IC50<1 nM) that inhibits lactate production in mouse hepatocytes. CHK-336 can be used in the study of hyperoxaluria[1].

Molecular Weight

530.57

Formula

C24H20F2N4O4S2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C1=CSC(N2N=C(C(CC3=CC=C(S(=O)(N)=O)C(F)=C3)=C2CC4CC4)C5=CC=C(F)C=C5)=N1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 130 mg/mL (245.02 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8848 mL 9.4238 mL 18.8477 mL
5 mM 0.3770 mL 1.8848 mL 3.7695 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8848 mL 9.4238 mL 18.8477 mL 47.1191 mL
5 mM 0.3770 mL 1.8848 mL 3.7695 mL 9.4238 mL
10 mM 0.1885 mL 0.9424 mL 1.8848 mL 4.7119 mL
15 mM 0.1257 mL 0.6283 mL 1.2565 mL 3.1413 mL
20 mM 0.0942 mL 0.4712 mL 0.9424 mL 2.3560 mL
25 mM 0.0754 mL 0.3770 mL 0.7539 mL 1.8848 mL
30 mM 0.0628 mL 0.3141 mL 0.6283 mL 1.5706 mL
40 mM 0.0471 mL 0.2356 mL 0.4712 mL 1.1780 mL
50 mM 0.0377 mL 0.1885 mL 0.3770 mL 0.9424 mL
60 mM 0.0314 mL 0.1571 mL 0.3141 mL 0.7853 mL
80 mM 0.0236 mL 0.1178 mL 0.2356 mL 0.5890 mL
100 mM 0.0188 mL 0.0942 mL 0.1885 mL 0.4712 mL
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CHK-336 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHK-3362743436-86-2CHK336CHK 336Lactate DehydrogenaseLDHhyperoxalurialactateInhibitorinhibitorinhibit

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