2. Membrane Transporter/Ion Channel
  3. Na+/K+ ATPase
  4. Chloroprocaine hydrochloride

Chloroprocaine hydrochloride  (Synonyms: 2-Chloroprocaine hydrochloride)

Cat. No.: HY-B1604 Purity: 99.89%
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Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve.

For research use only. We do not sell to patients.

Chloroprocaine hydrochloride Chemical Structure

Chloroprocaine hydrochloride Chemical Structure

CAS No. : 3858-89-7

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 90 In-stock
Solution
10 mM * 1 mL in DMSO USD 90 In-stock
Solid
5 mg USD 80 In-stock
10 mg USD 120 In-stock
25 mg USD 210 In-stock
50 mg USD 320 In-stock
100 mg USD 480 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Chloroprocaine hydrochloride:

Chloroprocaine hydrochloride Related Antibodies

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Description

Chloroprocaine hydrochloride (2-Chloroprocaine hydrochloride) is a potent inhibitor of Na,K-ATPase activity with an IC50 of 13 mM. Chloroprocaine hydrochloride blocks peripheral nerve[1].

IC50 & Target

IC50: 13 mM (Na,K-ATPase)[1]
In Vivo

In mice, the intravenous LD50 of Chloroprocaine hydrochloride is 97 mg/kg and the subcutaneous LD50 of Chloroprocaine hydrochloride is 950 mg/kg[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

307.22

Formula

C13H20Cl2N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(OCCN(CC)CC)C1=CC=C(N)C=C1Cl.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (325.50 mM; Need ultrasonic)

DMSO : 83.33 mg/mL (271.24 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2550 mL 16.2750 mL 32.5500 mL
5 mM 0.6510 mL 3.2550 mL 6.5100 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 6.25 mg/mL (20.34 mM); Clear solution

    This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.2550 mL 16.2750 mL 32.5500 mL 81.3749 mL
5 mM 0.6510 mL 3.2550 mL 6.5100 mL 16.2750 mL
10 mM 0.3255 mL 1.6275 mL 3.2550 mL 8.1375 mL
15 mM 0.2170 mL 1.0850 mL 2.1700 mL 5.4250 mL
20 mM 0.1627 mL 0.8137 mL 1.6275 mL 4.0687 mL
25 mM 0.1302 mL 0.6510 mL 1.3020 mL 3.2550 mL
30 mM 0.1085 mL 0.5425 mL 1.0850 mL 2.7125 mL
40 mM 0.0814 mL 0.4069 mL 0.8137 mL 2.0344 mL
50 mM 0.0651 mL 0.3255 mL 0.6510 mL 1.6275 mL
60 mM 0.0542 mL 0.2712 mL 0.5425 mL 1.3562 mL
80 mM 0.0407 mL 0.2034 mL 0.4069 mL 1.0172 mL
100 mM 0.0325 mL 0.1627 mL 0.3255 mL 0.8137 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Chloroprocaine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chloroprocaine3858-89-72-ChloroprocaineNa+/K+ ATPaseSodium potassium pumpanestheticNa,K-ATPaseInhibitorinhibitorinhibit

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