2. Metabolic Enzyme/Protease
  3. Liposome
  4. Cholesterol 5α,6α-epoxide

Cholesterol 5α,6α-epoxide  (Synonyms: 5α,6α-Epoxycholesterol)

Cat. No.: HY-133971 Purity: 98.40%
SDS COA Handling Instructions

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Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.

For research use only. We do not sell to patients.

Cholesterol 5α,6α-epoxide Chemical Structure

Cholesterol 5α,6α-epoxide Chemical Structure

CAS No. : 1250-95-9

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25 mg USD 40 In-stock
50 mg USD 65 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Cholesterol 5α,6α-epoxide:

Cholesterol 5α,6α-epoxide Related Antibodies

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Description

Cholesterol-5α,6α-epoxide is an epoxide derivative of cholesterol formed by the enzymatic oxidation of cholesterol in the liver and other tissues. Cholesterol-5α,6α-epoxide has unique chemical properties that make it an important intermediate in the biosynthesis of bile acids, which play a key role in the digestion and absorption of dietary fats. It also has a potential physiological role in regulating cholesterol metabolism and transport, although its biological function is not fully understood.

Cellular Effect
Cell Line Type Value Description References
HT-29 IC50
> 50 μM
Compound: 2
Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay
Cytotoxicity against human HT-29 cells after 48 hrs by Alamar blue assay
[PMID: 20931970]
HT-29 IC50
> 50 μM
Compound: 1a
Cytotoxicity against human HT-29 cells after 48 hrs by Alamar Blue assay
Cytotoxicity against human HT-29 cells after 48 hrs by Alamar Blue assay
[PMID: 19473028]
HT-29 IC50
37.8 μM
Compound: 2
Cytotoxicity against human HT-29 cells after 96 hrs by Alamar blue assay
Cytotoxicity against human HT-29 cells after 96 hrs by Alamar blue assay
[PMID: 20931970]
In Vitro

Cholesterol-5α,6α-epoxide is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cholesterol 5α,6α-epoxide Related Antibodies
Molecular Weight

402.65

Formula

C27H46O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])C[C@@]4([H])[C@@]5(O4)C[C@@H](O)CC[C@]5(C)[C@@]3([H])CC[C@]12C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 2.5 mg/mL (6.21 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4835 mL 12.4177 mL 24.8355 mL
5 mM 0.4967 mL 2.4835 mL 4.9671 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.40%

SDS (393 KB)

COA (251 KB) HNMR (281 KB) RP-HPLC (219 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4835 mL 12.4177 mL 24.8355 mL 62.0887 mL
5 mM 0.4967 mL 2.4835 mL 4.9671 mL 12.4177 mL
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Cholesterol 5α,6α-epoxide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cholesterol 5α,6α-epoxide1250-95-95α,6α-EpoxycholesterolLiposomebiochemical assayreagentInhibitorinhibitorinhibit

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