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  4. Chst15-IN-1

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair.

For research use only. We do not sell to patients.

Chst15-IN-1 Chemical Structure

Chst15-IN-1 Chemical Structure

CAS No. : 2158198-77-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 132 In-stock
Solution
10 mM * 1 mL in DMSO USD 132 In-stock
Solid
5 mg USD 95 In-stock
10 mg USD 150 In-stock
25 mg USD 285 In-stock
50 mg USD 450 In-stock
100 mg USD 730 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Chst15-IN-1 Related Antibodies

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  • Biological Activity

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Description

Chst15-IN-1 is a potent reversible covalent Chst15 inhibitor. Chst15-IN-1 effectively inhibits chondroitin sulfate-E (CS-E) sulfation levels and other closely related glycosaminoglycans (GAG) sulfotransferases. Chst15-IN-1, as a selective sulfotransferase inhibitor, can diminish the inhibitory effects of chondroitin sulfate proteoglycans (CSPGs), and can be used for the stimulation of neuronal repair[1].

IC50 & Target

Chst15[1]
In Vitro

Chst15-IN-1 (25 μM; 24 hours; Neu7 astrocytes) is selective for sulfotransferases over the myriad of reactive cysteine-containing proteins. Chst15-IN-1 (10 and 25 μM; Neu7 astrocytes) shows a significant dose dependent decrease in cell-surface CS-E expression[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chst15-IN-1 Related Antibodies
In Vivo

Chst15-IN-1 (3.0 mg/kg; i.v.) has a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 hours[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats
Dosage: 3.0 mg/kg (Pharmacokinetic Analysis)
Administration: I.v.
Result: Had a moderate clearance of 21 mL/min/kg, moderate volume of distribution of 0.97 L/kg, and short terminal half-life of 1.6 h.
Molecular Weight

442.09

Formula

C17H11BrCl2N2O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(NC1=CC=C(Cl)C=C1Cl)/C(C#N)=C/C2=CC(OC)=C(O)C(Br)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.10 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2620 mL 11.3099 mL 22.6198 mL
5 mM 0.4524 mL 2.2620 mL 4.5240 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2620 mL 11.3099 mL 22.6198 mL 56.5496 mL
5 mM 0.4524 mL 2.2620 mL 4.5240 mL 11.3099 mL
10 mM 0.2262 mL 1.1310 mL 2.2620 mL 5.6550 mL
15 mM 0.1508 mL 0.7540 mL 1.5080 mL 3.7700 mL
20 mM 0.1131 mL 0.5655 mL 1.1310 mL 2.8275 mL
25 mM 0.0905 mL 0.4524 mL 0.9048 mL 2.2620 mL
30 mM 0.0754 mL 0.3770 mL 0.7540 mL 1.8850 mL
40 mM 0.0565 mL 0.2827 mL 0.5655 mL 1.4137 mL
50 mM 0.0452 mL 0.2262 mL 0.4524 mL 1.1310 mL
60 mM 0.0377 mL 0.1885 mL 0.3770 mL 0.9425 mL
80 mM 0.0283 mL 0.1414 mL 0.2827 mL 0.7069 mL
100 mM 0.0226 mL 0.1131 mL 0.2262 mL 0.5655 mL
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Chst15-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chst15-IN-12158198-77-5Otherspotentreversiblecovalenteffectivelychondroitinsulfate-EGAGneuronalInhibitorinhibitorinhibit

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