2. Neuronal Signaling
  3. Monoamine Oxidase
  4. Clorgyline

Clorgyline  (Synonyms: M&B 9302)

Cat. No.: HY-14197 Purity: 99.76%
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Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases.

For research use only. We do not sell to patients.

Clorgyline Chemical Structure

Clorgyline Chemical Structure

CAS No. : 17780-72-2

Size Price Stock Quantity
5 mg USD 30 In-stock
10 mg USD 48 In-stock
25 mg USD 94 In-stock
50 mg USD 150 In-stock
100 mg USD 240 In-stock
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Based on 4 publication(s) in Google Scholar

Other Forms of Clorgyline:

Clorgyline Related Antibodies

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Description

Clorgyline (M&B 9302) is an orally active, blood-brain barrier permeable and selective monoamine oxidase A (MAO-A) inhibitor. Clorgyline's selective inhibition of MAO-A leads to reduced metabolism of neurotransmitters such as serotonin (5-hydroxytryptamine), which accumulates in the brain. Clorgyline can be used in the study of depression and neurodegenerative diseases[1].

Molecular Weight

272.17

Formula

C13H15Cl2NO
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

ClC1=CC=C(C(Cl)=C1)OCCCN(CC#C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (367.42 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6742 mL 18.3709 mL 36.7417 mL
5 mM 0.7348 mL 3.6742 mL 7.3483 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (9.19 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6742 mL 18.3709 mL 36.7417 mL 91.8544 mL
5 mM 0.7348 mL 3.6742 mL 7.3483 mL 18.3709 mL
10 mM 0.3674 mL 1.8371 mL 3.6742 mL 9.1854 mL
15 mM 0.2449 mL 1.2247 mL 2.4494 mL 6.1236 mL
20 mM 0.1837 mL 0.9185 mL 1.8371 mL 4.5927 mL
25 mM 0.1470 mL 0.7348 mL 1.4697 mL 3.6742 mL
30 mM 0.1225 mL 0.6124 mL 1.2247 mL 3.0618 mL
40 mM 0.0919 mL 0.4593 mL 0.9185 mL 2.2964 mL
50 mM 0.0735 mL 0.3674 mL 0.7348 mL 1.8371 mL
60 mM 0.0612 mL 0.3062 mL 0.6124 mL 1.5309 mL
80 mM 0.0459 mL 0.2296 mL 0.4593 mL 1.1482 mL
100 mM 0.0367 mL 0.1837 mL 0.3674 mL 0.9185 mL
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Clorgyline Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Clorgyline17780-72-2M&B 9302Monoamine OxidaseMAOSelective inhibitorsserotoninneurotransmittersneurodegenerative diseasesMAO-AInhibitorinhibitorinhibit

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