2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. CMP8

CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively.

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CMP8 Chemical Structure

CMP8 Chemical Structure

CAS No. : 851107-28-3

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Based on 1 publication(s) in Google Scholar

CMP8 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

CMP8, a selective ligand for estrogen receptor, binds to the mutant estrogen receptor ligand binding domain (ERLBD). CMP8 exhibits IC50 values of 29 nM , 41 nM, 1100 nM and 2200 nM for MGERα, MGRERα, hERα and hERβ, respectively[1][2].

IC50 & Target[2]

MGERα

29 nM (IC50)

MGRERα

41 nM (IC50)

hERα

1100 nM (IC50)

hERβ

2200 nM (IC50)

In Vivo

CMP8 (Compound 20h) is dosed in male Balb-c mice (4 mg/kg, ip). The plasma concentration after 4 h is 1.5-fold its EC50 in mammalian cells with a Cmax of 0.5 µM after 30 min[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

528.08

Formula

C33H34ClNO3
CAS No.
SMILES

O=C1CCC2(CC3=CC=C(Cl)C=C3)CC4=C(C=CC(O)=C4)C2=C1C5=CC=C(OCCN6CCCCC6)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CMP8 Related Classifications

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CMP8851107-28-3CMP 8CMP-8Estrogen Receptor/ERRInhibitorinhibitorinhibit

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