2. Anti-infection
  3. Bacterial
  4. COE-PNH2

COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC90 of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity.

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COE-PNH2 Chemical Structure

COE-PNH2 Chemical Structure

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COE-PNH2 Related Antibodies

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Description

COE-PNH2 exhibits antibacterial activity against Mycobacterium abscessus (Mab) with MIC90 of 26 μM. COE-PNH2 affects the integrity of the bacterial envelope and mycomembrane. COE-PNH2 reveals intracelluar penetration without mitochondrial toxicity[1].

In Vitro

COE-PNH2 (0-128 μg/mL) exhibits a stable antibacterial activity and extreme antibiotic tolerance against intracellular, replicating and nutrient-starved, non-replicating Mab[1].
COE-PNH2 exhibits a low propensity for resistance development with consistent MIC values in 14 passages of Mab[1].
COE-PNH2 (0-64 μg/mL) induces a depletion of ATP, accumulation of intracellular lipid inclusions (ILIs) and bacterial elongation in Mab[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

COE-PNH2 Related Antibodies
In Vivo

COE-PNH2 (2.5-5 mg/kg, intratracheal, every other day for 12 days) exhibits well tolerance and efficiency in acute lung infection in C3HeB/FeJ mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acute lung infection in C3HeB/FeJ mice[1]
Dosage: 2.5-5 mg/kg
Administration: Intratracheal administration every other day for 12 days
Result: Reduced the colony-forming units (CFU) and bacilli in lung without weight loss.
Molecular Weight

1207.03

Formula

C54H98Cl8N8O4
SMILES

C[N+](C)(CCCN)CCCOC1=CC(/C=C/C2=CC=C(/C=C/C3=CC(OCCC[N+](C)(CCCN)C)=CC(OCCC[N+](C)(CCCN)C)=C3)C=C2)=CC(OCCC[N+](C)(CCCN)C)=C1.[Cl-].[Cl-].[Cl-].[Cl-].Cl.Cl.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COE-PNH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COE-PNH2Bacterialmycobacterium abscessusTHP-1C3HeB/FeJ miceInhibitorinhibitorinhibit

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HY-158003
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