2. Immunology/Inflammation
  3. COX
  4. Flunixin

Flunixin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects.

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Flunixin Chemical Structure

Flunixin Chemical Structure

CAS No. : 38677-85-9

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Flunixin Related Antibodies

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Description

Flunixin is a cyclooxygenase (COX) inhibitor with IC50 values of 0.55 and 3.24 μM for COX-1 and COX-2, respectively. Flunixin shows anti-inflammatory effects[1][2].

IC50 & Target[2]

COX-1

0.55 μM (IC50)

COX-2

3.24 μM (IC50)

In Vitro

flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide (LPS)-induced activity of inducible nitric oxide synthase (iNOS) in RAW 264.7 murine macrophages[2].
flunixin meglumine (10-1000 μM, 2 h) inhibits lipopolysaccharide-induced activation of nuclear factor kappa B (NfκB) in RAW 264.7 murine macrophages[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Flunixin Related Antibodies

Cell Viability Assay[2]

Cell Line: RAW 264.7 murine macrophages
Concentration: 10, 100, 300, and 1000 μM
Incubation Time: 2 hours
Result: Inhibited LPS-induced nitric oxide release at concentrations between 100 and 1,000 µM (P=0.01).
In Vivo

Flunixin meglumine (intravenous injection; 1.1 mg/kg; once) treatment inhibits the formation of exudate PGE2 and serum TXB2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male sheep injected with Carrageenan[1]
Dosage: 1.1 mg/kg
Administration: Intravenous injection; 1.1 mg/kg; once
Result: Inhibited Carrageenan-induced exudate PGE2 formation (Emax, 100%, IC50, <0.4 nM) and serum TXB2 generation (Emax, 100%, IC50, 17 nM) for up to 32 h.
Molecular Weight

296.24

Formula

C14H11F3N2O2
CAS No.
SMILES

O=C(C1=CC=CN=C1NC2=CC=CC(C(F)(F)F)=C2C)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Flunixin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Flunixin38677-85-9Sch 14714Sch14714Sch-14714COXCyclooxygenaseanti-inflammatory effectRAW 264.7 murine macrophagesInhibitorinhibitorinhibit

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