Corticosterone-d₄

Name: Corticosterone-d 4
Brand: MedChemExpress
SKU: HY-B1618S1
Rating: 4.5 (1 reviews)

Cat. No.: HY-B1618S1 Purity: 99.17%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

For research use only. We do not sell to patients.

Corticosterone-d<sub>4</sub> Chemical Structure

Corticosterone-d₄ Chemical Structure

CAS No. : 2243253-91-8

Size	Price	Stock	Quantity
1 mg	USD 1280	In-stock	Estimated Time of Arrival: December 31
5 mg		Get quote
10 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Corticosterone-d₄:

Corticosterone In-stock

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Corticosterone-d₄ is the deuterium labeled Corticosterone. Corticosterone is an adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

350.49

Formula

C₂₁H₂₆D₄O₄

CAS No.

2243253-91-8

Unlabeled CAS

50-22-6

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@H](C(CO)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([2H])[C@](O)([2H])C2([2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (285.31 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 14.29 mg/mL (40.77 mM; Need ultrasonic)

H₂O : 0.67 mg/mL (1.91 mM; Need ultrasonic)

H₂O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8531 mL	14.2657 mL	28.5315 mL
5 mM	0.5706 mL	2.8531 mL	5.7063 mL
10 mM	0.2853 mL	1.4266 mL	2.8531 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.17%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (256 KB) HNMR (222 KB) RP-HPLC (205 KB) MS (189 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Gasser PJ, et al. Corticosterone-sensitive monoamine transport in the rat dorsomedial hypothalamus: potential role for organiccation transporter 3 in stress-induced modulation of monoaminergic neurotransmission. J Neurosci. 2006 Aug 23;26(34):8758-8766. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / Ethanol / Ethanol / DMSO / DMSO	1 mM	2.8531 mL	14.2657 mL	28.5315 mL	71.3287 mL
Ethanol / Ethanol / DMSO / DMSO	5 mM	0.5706 mL	2.8531 mL	5.7063 mL	14.2657 mL
	10 mM	0.2853 mL	1.4266 mL	2.8531 mL	7.1329 mL
	15 mM	0.1902 mL	0.9510 mL	1.9021 mL	4.7552 mL
	20 mM	0.1427 mL	0.7133 mL	1.4266 mL	3.5664 mL
	25 mM	0.1141 mL	0.5706 mL	1.1413 mL	2.8531 mL
	30 mM	0.0951 mL	0.4755 mL	0.9510 mL	2.3776 mL
	40 mM	0.0713 mL	0.3566 mL	0.7133 mL	1.7832 mL
DMSO / DMSO	50 mM	0.0571 mL	0.2853 mL	0.5706 mL	1.4266 mL
	60 mM	0.0476 mL	0.2378 mL	0.4755 mL	1.1888 mL
	80 mM	0.0357 mL	0.1783 mL	0.3566 mL	0.8916 mL
	100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.7133 mL