Coumarin 106 (Synonyms: Coumarin 478)

Cat. No.: HY-W324391 Purity: 99.76%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56).

For research use only. We do not sell to patients.

Coumarin 106 Chemical Structure

CAS No. : 41175-45-5

Size	Price	Stock	Quantity
10 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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References
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Description

In Vitro

Coumarin 106 is non-toxic in Caco-2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

281.35

Formula

C₁₈H₁₉NO₂

CAS No.

41175-45-5

Appearance

Solid

Color

Light green to green

SMILES

O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C5=C1CCC5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 25 mg/mL (88.86 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5543 mL	17.7715 mL	35.5429 mL
5 mM	0.7109 mL	3.5543 mL	7.1086 mL
10 mM	0.3554 mL	1.7771 mL	3.5543 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.76%

Select Batch:

Data Sheet (276 KB) SDS (393 KB)

COA (255 KB) HNMR (249 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. [Content Brief]

[2]. Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5543 mL	17.7715 mL	35.5429 mL	88.8573 mL
	5 mM	0.7109 mL	3.5543 mL	7.1086 mL	17.7715 mL
	10 mM	0.3554 mL	1.7771 mL	3.5543 mL	8.8857 mL
	15 mM	0.2370 mL	1.1848 mL	2.3695 mL	5.9238 mL
	20 mM	0.1777 mL	0.8886 mL	1.7771 mL	4.4429 mL
	25 mM	0.1422 mL	0.7109 mL	1.4217 mL	3.5543 mL
	30 mM	0.1185 mL	0.5924 mL	1.1848 mL	2.9619 mL
	40 mM	0.0889 mL	0.4443 mL	0.8886 mL	2.2214 mL
	50 mM	0.0711 mL	0.3554 mL	0.7109 mL	1.7771 mL
	60 mM	0.0592 mL	0.2962 mL	0.5924 mL	1.4810 mL
	80 mM	0.0444 mL	0.2221 mL	0.4443 mL	1.1107 mL

Coumarin 106 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Coumarin 10641175-45-5Coumarin 478Coumarin106Coumarin-106Coumarin478Coumarin-478Cholinesterase (ChE)Inhibitorinhibitorinhibit

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