Coumarin 106 (Synonyms: Coumarin 478)

Cat. No.: HY-W324391: FAQs
Data Sheet SDS COA Handling Instructions

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Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56).

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Coumarin 106 Chemical Structure

CAS No. : 41175-45-5

Size	Price	Stock	Quantity
10 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 80	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
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Description	Coumarin 106 (Coumarin 478) is a dipolar laser dye. Coumarin 106 is an inhibitor of AChE and BChE. Coumarin 106 displays mixed-type AChE inhibition with a pIC₅₀=4.97 and K_i=2.36 μM. Coumarin 106 inhibits BChE with slightly lower potency (pIC₅₀=4.56)^[1]^[2].
In Vitro	Coumarin 106 is non-toxic in Caco-2 cells^[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Coumarin 106 Related Antibodies
Molecular Weight	281.35
Formula	C₁₈H₁₉NO₂
CAS No.	41175-45-5
Appearance	Solid
Color	Light green to green
SMILES	O=C1OC2=C(C=C3C4=C2CCCN4CCC3)C5=C1CCC5
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Purity & Documentation	Purity: 99.76% Select Batch: Data Sheet (272 KB) SDS (393 KB) COA (255 KB) HNMR (249 KB) LCMS (90 KB) Handling Instructions (2659 KB)
References	[1]. Patil SK, et al. Determination of ground and excited state dipole moments of dipolar laser dyes by solvatochromic shift method. Spectrochim Acta A Mol Biomol Spectrosc. 2014 Apr 5;123:117-26. [Content Brief] [2]. Fallarero A, et al. Inhibition of acetylcholinesterase by coumarins: the case of coumarin 106. Pharmacol Res. 2008 Sep-Oct;58(3-4):215-21. [Content Brief]

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Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Coumarin 10641175-45-5Coumarin 478Coumarin106Coumarin-106Coumarin478Coumarin-478Cholinesterase (ChE)Inhibitorinhibitorinhibit

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