COX-2-IN-10 

COX-2-IN-10 is a potent COX-2 inhibitor. COX-2-IN-10 inhibits the production of PGE₂ in concentration dependent manner (IC₅₀=2.54 µM). COX-2-IN-10 inhibits the expression of iNOS and COX-2 on mRNA and protein level . COX-2-IN-10 inhibits the production of IL-6, TNF-α and IL-1β^[1].

COX-2-IN-10 (compound 9k) (10 µM, 24 h) exhibits high safety and did not show any significant cytotoxicity over LPS-Induced RAW264.7 macrophage cells^[1].
COX-2-IN-10 (0.4, 2, 10 µM) inhibits the production of PGE₂ in concentration dependent manner in RAW264.7 macrophage cells (IC₅₀=2.54 µM)^[1].
COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits the mRNA expression of iNOS and COX-2 at 10 μM^[1].
COX-2-IN-10 (2.5, 5, 10 μM) significantly inhibits iNOS and COX-2 protein level starting from 10 μM concentration^[1].
COX-2-IN-10 (2.5, 5, 10 μM; 1 h) inhibits the production of IL-6, TNF-α and IL-1β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

557.68

C₃₁H₃₂FN₅O₂S

CC(C)(N1C=C(C(C2=CC(F)=CC=C2)=N1)C3=CC=NC(NCCCNS(=O)(C4=CC5=C(C=C4)C=CC=C5)=O)=C3)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Karim I. M, et al. Design, synthesis, in vitro determination and molecular docking studies of 4-(1-(tert-butyl)-3-phenyl-1H-pyrazol-4-yl) pyridine derivatives with terminal sulfonamide derivatives in LPS-induced RAW264.7 macrophage cells. Medicinal Chemis