2. Immunology/Inflammation
  3. COX
  4. COX-2-IN-16

COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity.

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COX-2-IN-16 Chemical Structure

COX-2-IN-16 Chemical Structure

CAS No. : 1610894-92-2

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COX-2-IN-16 Related Antibodies

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Description

COX-2-IN-16 (compound 2b) is a potent, selective and orally active COX-2 inhibitor with an IC50 of 102 µM. COX-2-IN-16 inhibits the NO production. COX-2-IN-16 shows anti-inflammatory activity[1].

IC50 & Target[1]

COX-2

102 μM (IC50)

In Vivo

COX-2-IN-16 (compound 2b) (100 mg/kg; p.o.) shows better reduction in the edema formation by 42% in a rat paw edema model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

394.22

Formula

C19H12BrN3O2
CAS No.
SMILES

O=[N+](C1=CC=C(C=C1)N2C3=CC=CC=C3N=C2C4=CC=C(C=C4)Br)[O-]
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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COX-2-IN-16 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

COX-2-IN-161610894-92-2COXCyclooxygenaseanti-inflammatoryNOorally activerat paw edema modelInhibitorinhibitorinhibit

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