Arglabin (Synonyms: (+)-Arglabin)

Name: Arglabin
Brand: MedChemExpress
SKU: HY-16059
Rating: 4.5 (1 reviews)

Cat. No.: HY-16059 Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

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Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene.

For research use only. We do not sell to patients.

Arglabin Chemical Structure

CAS No. : 84692-91-1

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 396	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 396	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 146	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 308	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 495	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 660	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 880	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1320	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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NLRP3 NLRP1 NOD1 NOD2

Biological Activity
Purity & Documentation
References
Customer Review

Description

Arglabin ((+)-Arglabin), a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor. Arglabin shows anti-inflammatory and antitumor activities^[1]. The antitumor activity of Arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene^[2].

IC₅₀ & Target

NLRP3

Cellular Effect

Cell Line	Type	Value	Description	References
518A2	IC₅₀	6.72 μM Compound: 203	Cytotoxicity against human 518A2 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human 518A2 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
A2780	IC₅₀	12.55 μM Compound: 11m	Cytotoxicity against human A2780 cells assessed as inhibition of cell growth incubated for 96 hrs by SRB assay Cytotoxicity against human A2780 cells assessed as inhibition of cell growth incubated for 96 hrs by SRB assay	[PMID: 32526552]
A-431	IC₅₀	4.48 μM Compound: 203	Cytotoxicity against human A431 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human A431 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
A549	IC₅₀	2.21 μM Compound: 203	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
HT-29	IC₅₀	7 μM Compound: 203	Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human HT-29 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]
MCF7	IC₅₀	2.33 μM Compound: 203	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB asssay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 96 hrs by SRB asssay	[PMID: 27996267]

In Vitro

The antitumor activity of arglabin proceeds through its inhibition of farnesyl transferase which leads to the activation of RAS proto-oncogene, a process that is believed to play a pivotal role in 20-30% of all human tumors. It actually inhibits the incorporation of farnesyl pyrophosphate into human H-ras proteins by the enzyme farnesyl transferase (FTase)^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Arglabin reduces inflammation and plasma lipids, increases autophagy, and orients tissue macrophages into an anti-inflammatory phenotype in ApoE2.Ki mice fed a high-fat diet^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

246.31

Formula

C₁₅H₁₈O₃

CAS No.

84692-91-1

Appearance

Solid

Color

White to light yellow

SMILES

C[C@]1(CC[C@](C2=C)([H])[C@@](OC2=O)([H])[C@@]3([H])C(C)=CC4)[C@]34O1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (406.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0600 mL	20.3000 mL	40.5999 mL
5 mM	0.8120 mL	4.0600 mL	8.1200 mL
10 mM	0.4060 mL	2.0300 mL	4.0600 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.15 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (277 KB) SDS (392 KB)

COA (254 KB) LCMS (262 KB)

Handling Instructions (2659 KB)

References

[1]. Abderrazak A, et al. Anti-inflammatory and antiatherogenic effects of the NLRP3 inflammasome inhibitor arglabin in ApoE2.Ki mice fed a high-fat diet. Circulation. 2015;131(12):1061-1070. [Content Brief]

[2]. Lone SH, et al. Arglabin: From isolation to antitumor evaluation. Chem Biol Interact. 2015;240:180-198. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0600 mL	20.3000 mL	40.5999 mL	101.4998 mL
	5 mM	0.8120 mL	4.0600 mL	8.1200 mL	20.3000 mL
	10 mM	0.4060 mL	2.0300 mL	4.0600 mL	10.1500 mL
	15 mM	0.2707 mL	1.3533 mL	2.7067 mL	6.7667 mL
	20 mM	0.2030 mL	1.0150 mL	2.0300 mL	5.0750 mL
	25 mM	0.1624 mL	0.8120 mL	1.6240 mL	4.0600 mL
	30 mM	0.1353 mL	0.6767 mL	1.3533 mL	3.3833 mL
	40 mM	0.1015 mL	0.5075 mL	1.0150 mL	2.5375 mL
	50 mM	0.0812 mL	0.4060 mL	0.8120 mL	2.0300 mL
	60 mM	0.0677 mL	0.3383 mL	0.6767 mL	1.6917 mL
	80 mM	0.0507 mL	0.2537 mL	0.5075 mL	1.2687 mL
	100 mM	0.0406 mL	0.2030 mL	0.4060 mL	1.0150 mL

Arglabin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Arglabin84692-91-1(+)-ArglabinNOD-like Receptor (NLR)Farnesyl TransferaseAutophagyFtaseinflammasomeanti-inflammatoryantitumorRASproto-oncogeneInhibitorinhibitorinhibit

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Arglabin (Synonyms: (+)-Arglabin)

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Arglabin Related Antibodies

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Complete Stock Solution Preparation Table

Arglabin Related Classifications

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