2. Epigenetics
  3. Histone Demethylase
  4. CPI-4203

CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent.

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CPI-4203 Chemical Structure

CPI-4203 Chemical Structure

CAS No. : 1628214-07-2

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5 mg USD 270 In-stock
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Based on 1 publication(s) in Google Scholar

CPI-4203 Related Antibodies

Top Publications Citing Use of Products

View All Histone Demethylase Isoform Specific Products:

View All Isoforms
KDM1/LSD1 KDM2 KDM3 KDM4 KDM5 KDM6

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Description

CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent[1].

IC50 & Target

IC50: 250 nM (KDM5A)[1]
Molecular Weight

278.31

Formula

C16H14N4O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(N2N=C1)NC(C3=C(C=CC=C3)C)=C(C2=O)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (89.83 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5931 mL 17.9656 mL 35.9312 mL
5 mM 0.7186 mL 3.5931 mL 7.1862 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C1

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.5931 mL 17.9656 mL 35.9312 mL 89.8279 mL
5 mM 0.7186 mL 3.5931 mL 7.1862 mL 17.9656 mL
10 mM 0.3593 mL 1.7966 mL 3.5931 mL 8.9828 mL
15 mM 0.2395 mL 1.1977 mL 2.3954 mL 5.9885 mL
20 mM 0.1797 mL 0.8983 mL 1.7966 mL 4.4914 mL
25 mM 0.1437 mL 0.7186 mL 1.4372 mL 3.5931 mL
30 mM 0.1198 mL 0.5989 mL 1.1977 mL 2.9943 mL
40 mM 0.0898 mL 0.4491 mL 0.8983 mL 2.2457 mL
50 mM 0.0719 mL 0.3593 mL 0.7186 mL 1.7966 mL
60 mM 0.0599 mL 0.2994 mL 0.5989 mL 1.4971 mL
80 mM 0.0449 mL 0.2246 mL 0.4491 mL 1.1228 mL
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CPI-4203 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CPI-42031628214-07-2CPI4203CPI 4203Histone DemethylaseInhibitorinhibitorinhibit

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