2. Protein Tyrosine Kinase/RTK
  3. c-Fms
  4. CSF1R-IN-23

CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable.

For research use only. We do not sell to patients.

CSF1R-IN-23 Chemical Structure

CSF1R-IN-23 Chemical Structure

CAS No. : 2935480-17-2

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CSF1R-IN-23 Related Antibodies

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Description

CSF1R-IN-23 (Compound 7dri) is a selective inhibitor for colony-stimulating factor-1 receptor (CSF1R), with IC50 of 36.1 nM. CSF1R-IN-23 serves as antineuroinflammatory agent in mouse model. CSF1R-IN-23 is blood brain barrier (BBB) permeable[1].

In Vitro

CSF1R-IN-23 (0-10 μM, 30 min) inhibits autophosphorylation of CSF1R in cells RAW264.7 and microglial cells EOC20, without significant cytotoxicity[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CSF1R-IN-23 Related Antibodies

Western Blot Analysis[1]

Cell Line: EOC20 and RAW264.7
Concentration: 0-10 μM
Incubation Time: 30 min
Result: Inhibited phosphorylation of CSF1R.
In Vivo

CSF1R-IN-23 (0.5 mg/kg, i.p. every two days for 4 doses) ameliorates the Lipopolysaccharide (HY-D1056)-induced neuroinflammation in C57BL/6J mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced neuroinflammation in C57BL/6J mice model[1]
Dosage: 0.5 mg/kg
Administration: i.p., every two days for 4 doses
Result: Eliminated the 76% microglias in hippocampus, cortex, and thalamus.
Molecular Weight

435.60

Formula

C27H37N3O2
CAS No.
SMILES

CC1(NC(C)(CC(C1)C2=CC(C3=CCC(CC3)C)=C(C=C2)NC(C4=NOC(C)=C4)=O)C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CSF1R-IN-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CSF1R-IN-232935480-17-2c-FmsCSF-1 receptorcolony stimulating factor 1 receptorCSF-1RCSF1RAlzheimer’s diseaseneurodegenerative diseasesRAW264.7EOC20BBB permeableC57BL/6J miceInhibitorinhibitorinhibit

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