2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. CU-CPD107

CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA.

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CU-CPD107 Chemical Structure

CU-CPD107 Chemical Structure

CAS No. : 2573912-32-8

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1 mg USD 75 In-stock
5 mg USD 168 In-stock
10 mg USD 270 In-stock
25 mg USD 495 In-stock
50 mg USD 700 In-stock
100 mg USD 990 In-stock
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Based on 1 publication(s) in Google Scholar

CU-CPD107 Related Antibodies

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

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Description

CU-CPD107 is a potent, selective toll-like receptor 8 (TLR 8) agonist. CU-CPD107 inhibits TLR8 signaling. CU-CPD107 converts to synergistic agonist activities in the presence of ssRNA and induces TLR8 signaling. CU-CPD107 inhibits proinflammatory factor expression and avoids immune responses in the presence of ssRNA[1].

In Vitro

CU-CPD107 (HEK-Blue hTLR8 cells) inhibits R848-induced signaling with an IC50 value of 13.7 µM[1].
CU-CPD107 (0-100 µM; HEK-Blue hTLR8 cells) converts to an agonist in the presence of ssRNA[1].
CU-CPD107 (100 µM; HEK-Blue hTLR8 cells) decreases IFN-β, TNF-α, IL-1β, IL-6 and IL-8 mRNA expression levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CU-CPD107 Related Antibodies
Molecular Weight

400.25

Formula

C16H21IN2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

IC1=C(C2=CC=CC=C2)N(CC(C)(C)O)C(COCC)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (312.30 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4984 mL 12.4922 mL 24.9844 mL
5 mM 0.4997 mL 2.4984 mL 4.9969 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4984 mL 12.4922 mL 24.9844 mL 62.4610 mL
5 mM 0.4997 mL 2.4984 mL 4.9969 mL 12.4922 mL
10 mM 0.2498 mL 1.2492 mL 2.4984 mL 6.2461 mL
15 mM 0.1666 mL 0.8328 mL 1.6656 mL 4.1641 mL
20 mM 0.1249 mL 0.6246 mL 1.2492 mL 3.1230 mL
25 mM 0.0999 mL 0.4997 mL 0.9994 mL 2.4984 mL
30 mM 0.0833 mL 0.4164 mL 0.8328 mL 2.0820 mL
40 mM 0.0625 mL 0.3123 mL 0.6246 mL 1.5615 mL
50 mM 0.0500 mL 0.2498 mL 0.4997 mL 1.2492 mL
60 mM 0.0416 mL 0.2082 mL 0.4164 mL 1.0410 mL
80 mM 0.0312 mL 0.1562 mL 0.3123 mL 0.7808 mL
100 mM 0.0250 mL 0.1249 mL 0.2498 mL 0.6246 mL
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CU-CPD107 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CU-CPD1072573912-32-8Toll-like Receptor (TLR)TLR8 signalingssRNAsynergistic agonistproinflammatory factorInhibitorinhibitorinhibit

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