2. Apoptosis
  3. Apoptosis
  4. CWI1-2 hydrochloride

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects.

For research use only. We do not sell to patients.

CWI1-2 hydrochloride Chemical Structure

CWI1-2 hydrochloride Chemical Structure

CAS No. : 2408590-37-2

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5 mg USD 125 In-stock
10 mg USD 190 In-stock
25 mg USD 380 In-stock
50 mg USD 550 In-stock
100 mg USD 780 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of CWI1-2 hydrochloride:

CWI1-2 hydrochloride Related Antibodies

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Description

CWI1-2 hydrochloride is an IGF2BP2 inhibitor that binds IGF2BP2 and inhibits its interaction with m6A-modified target transcripts, induces apoptosis and differentiation, and shows promising anti-leukemic effects[1].

In Vitro

CWI1-2 (0-1 μM, 24 h) hydrochloride has good anti-leukemic efficacy[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CWI1-2 hydrochloride Related Antibodies

Apoptosis Analysis[1]

Cell Line: MonoMac6, MOLM13
Concentration: 0-1 μM
Incubation Time: 24 h
Result: Induced significant cell differentiation and apoptosis in a concentration-dependent manner in IGF2BP2-high cells but not in IGF2BP2-low cells.
Reduced Gln uptake and impaired mitochondrial function, resulting in reduced ATP production in AML cells.
Significantly inhibited the colony-forming ability of MA9-induced leukemic mouse blasts and greatly impairs the self-renewal of LSC/LIC.
In Vivo

CWI1-2 (5 mg/kg, i.v., once daily, 7-10 days) hydrochloride can significantly delay the onset of leukemia and prolong the survival time of BMT recipient B6.SJL (CD45.1) mice without any loss in body weight[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

556.23

Formula

C22H18Cl4N6O3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC(C=C1)=C(C=C1Cl)/C=N/N=C(N/N=C\C(C=C2Cl)=C(C=C2)O)\N/N=C/C(C=C3Cl)=C(C=C3)O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (224.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7978 mL 8.9891 mL 17.9782 mL
5 mM 0.3596 mL 1.7978 mL 3.5956 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7978 mL 8.9891 mL 17.9782 mL 44.9454 mL
5 mM 0.3596 mL 1.7978 mL 3.5956 mL 8.9891 mL
10 mM 0.1798 mL 0.8989 mL 1.7978 mL 4.4945 mL
15 mM 0.1199 mL 0.5993 mL 1.1985 mL 2.9964 mL
20 mM 0.0899 mL 0.4495 mL 0.8989 mL 2.2473 mL
25 mM 0.0719 mL 0.3596 mL 0.7191 mL 1.7978 mL
30 mM 0.0599 mL 0.2996 mL 0.5993 mL 1.4982 mL
40 mM 0.0449 mL 0.2247 mL 0.4495 mL 1.1236 mL
50 mM 0.0360 mL 0.1798 mL 0.3596 mL 0.8989 mL
60 mM 0.0300 mL 0.1498 mL 0.2996 mL 0.7491 mL
80 mM 0.0225 mL 0.1124 mL 0.2247 mL 0.5618 mL
100 mM 0.0180 mL 0.0899 mL 0.1798 mL 0.4495 mL
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CWI1-2 hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CWI1-22408590-37-2ApoptosisIGF2BP2m6Aapoptosisdifferentiationanti-leukemicInhibitorinhibitorinhibit

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CWI1-2 hydrochloride
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