Cyclopropavir (Synonyms: Filociclovir; ZSM-I-62; MBX-400)

Cat. No.: HY-16721 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Cyclopropavir (Filociclovir; ZSM-I-62; MBX-400) is a broad-spectrum anti-herpesvirus compound, has good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8 with EC₅₀s of 0.7 μM to 8 μM.

For research use only. We do not sell to patients.

Cyclopropavir Chemical Structure

CAS No. : 632325-71-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
BSC-1	EC₅₀	> 100 μM Compound: 2b	Antiviral activity against Herpes simplex virus type 1 in african green monkey BSC1 cells by ELISA Antiviral activity against Herpes simplex virus type 1 in african green monkey BSC1 cells by ELISA	[PMID: 19410465]
CCRF-HSB-2	CC₅₀	> 20 μM Compound: CPV	Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human HSB2 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
Fibroblast	EC₅₀	0.46 μM Compound: 3b	Antiviral activity against Human cytomegalovirus Towne infected in human foreskin fibroblast cells by plaque reduction assay Antiviral activity against Human cytomegalovirus Towne infected in human foreskin fibroblast cells by plaque reduction assay	[PMID: 19397271]
HFF	IC₅₀	> 100 μM Compound: CPV	Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-1 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HFF	IC₅₀	> 100 μM Compound: CPV	Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining Antiviral activity against HSV-2 infected in human HFF cells assessed as reduction in cytopathic effect after 3 days by crystal violet staining	[PMID: 22607883]
HFF	IC₅₀	> 100 μM Compound: CPV	Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining Antiviral activity against VZV infected in human HFF cells assessed as reduction in cytopathic effect after 7 days by crystal violet staining	[PMID: 22607883]
HFF	CC₅₀	> 100 μM Compound: 3b	Cytotoxicity against HFF cells by neutral red uptake assay Cytotoxicity against HFF cells by neutral red uptake assay	[PMID: 19397271]
HFF	CC₅₀	> 100 μM Compound: 2b	Cytotoxicity against HFF by visual cytotoxicity assay Cytotoxicity against HFF by visual cytotoxicity assay	[PMID: 19410465]
HFF	CC₅₀	> 100 μM Compound: 3b	Cytotoxicity against HFF cells by plaque reduction assay Cytotoxicity against HFF cells by plaque reduction assay	[PMID: 19397271]
HFF	CC₅₀	> 300 μM Compound: CPV	Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining Cytotoxicity against human HFF cells after 3 to 8 days by crystal voilet staining	[PMID: 22607883]
HFF	CC₅₀	> 380 μM Compound: 2b	Cytotoxicity against HFF by neutral red uptake assay Cytotoxicity against HFF by neutral red uptake assay	[PMID: 19410465]
HFF	CC₅₀	> 380 μM Compound: 1a	Cytotoxic concentration against AD169 strain of human cytomegalovirus infected HFF cells of human (by neutral red uptake) Cytotoxic concentration against AD169 strain of human cytomegalovirus infected HFF cells of human (by neutral red uptake)	[PMID: 15634003]
HFF	IC₅₀	1.4 μM Compound: CPV	Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay Antiviral activity against HCMV infected in human HFF cells assessed as reduction in cytopathic effect after 8 days by plaque reduction assay	[PMID: 22607883]
MOLT-3	CC₅₀	> 20 μM Compound: CPV	Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay Cytotoxicity against human MOLT3 cells after 7 days by Cell-Titer Glo assay	[PMID: 22607883]
MOLT-3	IC₅₀	8 μM Compound: CPV	Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay Antiviral activity against HHV-6B infected in human Molt3 cells assessed as reduction in viral DNA after 7 days by hybridization assay	[PMID: 22607883]
WI-38	CC₅₀	> 100 μM Compound: Cyclopropavir	Cytotoxicity against human WI38 cells by neutral red assay Cytotoxicity against human WI38 cells by neutral red assay	[PMID: 18285481]
WI-38	EC₅₀	> 100 μM Compound: Cyclopropavir	Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis Antimicrobial activity against BK polyomavirus ATCC VR837 infected in human WI38 cells assessed as reduction in viral titer after 7 days by PCR analysis	[PMID: 18285481]

Clinical Trial

Molecular Weight

263.26

Formula

C₁₁H₁₃N₅O₃

CAS No.

632325-71-4

Appearance

Solid

Color

White to off-white

SMILES

OCC(/C1=C/N2C3=C(C(N=C(N)N3)=O)N=C2)(C1)CO.[(Z)]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (126.60 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.7985 mL	18.9926 mL	37.9853 mL
5 mM	0.7597 mL	3.7985 mL	7.5971 mL
10 mM	0.3799 mL	1.8993 mL	3.7985 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (249 KB) HNMR (261 KB)

Handling Instructions (2659 KB)

References

[1]. Kern ER, et al. In vitro activity and mechanism of action of methylenecyclopropane analogs of nucleosides against herpesvirus replication. Antimicrob Agents Chemother. 2005 Mar;49(3):1039-45. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.7985 mL	18.9926 mL	37.9853 mL	94.9632 mL
	5 mM	0.7597 mL	3.7985 mL	7.5971 mL	18.9926 mL
	10 mM	0.3799 mL	1.8993 mL	3.7985 mL	9.4963 mL
	15 mM	0.2532 mL	1.2662 mL	2.5324 mL	6.3309 mL
	20 mM	0.1899 mL	0.9496 mL	1.8993 mL	4.7482 mL
	25 mM	0.1519 mL	0.7597 mL	1.5194 mL	3.7985 mL
	30 mM	0.1266 mL	0.6331 mL	1.2662 mL	3.1654 mL
	40 mM	0.0950 mL	0.4748 mL	0.9496 mL	2.3741 mL
	50 mM	0.0760 mL	0.3799 mL	0.7597 mL	1.8993 mL
	60 mM	0.0633 mL	0.3165 mL	0.6331 mL	1.5827 mL
	80 mM	0.0475 mL	0.2374 mL	0.4748 mL	1.1870 mL
	100 mM	0.0380 mL	0.1899 mL	0.3799 mL	0.9496 mL

Cyclopropavir Related Classifications

Infection

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cyclopropavir632325-71-4Filociclovir ZSM-I-62 MBX-400MBX400MBX 400MBX-400CMVHSVCytomegalovirusHerpes simplex virusInhibitorinhibitorinhibit

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Cyclopropavir (Synonyms: Filociclovir; ZSM-I-62; MBX-400)

Customer Review

Cyclopropavir Related Antibodies

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All HSV Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Cyclopropavir Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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