Cycrimine

Cat. No.: HY-119918 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

Cycrimine is an orally active muscarinic cholinergic receptor (mAChR) M1 antagonist, reduces the acetylcholine levels in parkinson model. Cycrimine shows antispasmodic activity, can be used in studies of behavioral and mental disorder.

For research use only. We do not sell to patients.

Cycrimine Chemical Structure

CAS No. : 77-39-4

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

287.44

Formula

C₁₉H₂₉NO

CAS No.

77-39-4

Appearance

Solid

Color

White to off-white

SMILES

OC(C1CCCC1)(C2=CC=CC=C2)CCN3CCCCC3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (86.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4790 mL	17.3949 mL	34.7899 mL
5 mM	0.6958 mL	3.4790 mL	6.9580 mL
10 mM	0.3479 mL	1.7395 mL	3.4790 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (249 KB)

Handling Instructions (2659 KB)

References

[1]. David T. CHAU. Methods of treating behaviorial and/or mental disorders. WO2014176460A1.

[2]. Marzoughi S, et al. Tardive neurotoxicity of anticholinergic drugs: A review. J Neurochem. 2021 Sep;158(6):1334-1344. [Content Brief]

[3]. Tacke, et al. Syntheses and pharmacological characterization of achiral and chiral enantiopure C/Si/Ge-analogous derivatives of the muscarinic antagonist cycrimine: a study on C/Si/Ge bioisosterism. Journal of organometallic chemistry 640.1-2 (2001): 140-

[4]. MAGEE KR, et al. Antispasmodic compound 08958 in treatment of paralysis agitans. J Am Med Assoc. 1953 Oct 24;153(8):715-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.4790 mL	17.3949 mL	34.7899 mL	86.9747 mL
	5 mM	0.6958 mL	3.4790 mL	6.9580 mL	17.3949 mL
	10 mM	0.3479 mL	1.7395 mL	3.4790 mL	8.6975 mL
	15 mM	0.2319 mL	1.1597 mL	2.3193 mL	5.7983 mL
	20 mM	0.1739 mL	0.8697 mL	1.7395 mL	4.3487 mL
	25 mM	0.1392 mL	0.6958 mL	1.3916 mL	3.4790 mL
	30 mM	0.1160 mL	0.5798 mL	1.1597 mL	2.8992 mL
	40 mM	0.0870 mL	0.4349 mL	0.8697 mL	2.1744 mL
	50 mM	0.0696 mL	0.3479 mL	0.6958 mL	1.7395 mL
	60 mM	0.0580 mL	0.2899 mL	0.5798 mL	1.4496 mL
	80 mM	0.0435 mL	0.2174 mL	0.4349 mL	1.0872 mL

Cycrimine Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cycrimine77-39-4mAChRMuscarinic acetylcholine receptorParkinsonAchmental disorderbehavioral disordermuscarinicanticholinergicPDInhibitorinhibitorinhibit

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Cycrimine

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Cycrimine Related Antibodies

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Molarity Calculator

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Complete Stock Solution Preparation Table

Cycrimine Related Classifications

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