2. Anti-infection Membrane Transporter/Ion Channel
  3. Parasite Potassium Channel
  4. Cymarin

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K+ release (IC50=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant.

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Cymarin Chemical Structure

Cymarin Chemical Structure

CAS No. : 508-77-0

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Cymarin Related Antibodies

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Description

Cymarin, a cardiac glycoside, potently inhibits the Palytoxin (PTX)-induced K+ release (IC50=0.42 μM). Cymarin reveals an antitumor activity against breast cancer and pancreatic cancer. Cymarin exhibits antifeedant and growth inhibitory effects as crop protectant[1][2][3][4].
In Vitro

Cymarin (0.25-1 μM) inhibites PAX6 expression by blocking IRES-directed translation and inhibits 47.8% proliferation of MCF-7 cells with the concentration of 1 μM [2].
Cymarin downregulates UGT1A10 expression, eliminates TRA-1-60 (IC50 of 15.2 nM) and TRA-1-81 cells (IC50 of 5.1 nM) in cell lines SW1990GR, inhibits proliferations and cell viabilities of pancreatic cancer cells SW1990 and SW1990GR (IC50 of 33.8 nM for SW1990 and 40.8 nM for SW1990GR)[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cymarin Related Antibodies

Cell Viability Assay[4]

Cell Line: SW1990 and SW1990GR
Concentration: 0-500 nM
Incubation Time: 72 h
Result: Decreased cell viability with IC50 of 33.8 nM for SW1990 and 40.8 for SW1990GR.

Cell Proliferation Assay[2]

Cell Line: MCF-7
Concentration: 0.25-1 μM
Incubation Time: 5 days
Result: Inhibits proliferation of MCF-7 cells in a dose-dependent manner.

Western Blot Analysis[2]

Cell Line: MCF-7
Concentration: 0.25-1 μM
Incubation Time: 24 h
Result: Downregulated levels of PAX6.

Real Time qPCR[4]

Cell Line: SW1990 and SW1990GR
Concentration: 7-15 μM
Incubation Time:
Result: Decreased levels of UGT1A10 transcription.
In Vivo

Cymarin inhibits growth of neonate Trichoplusia ni larvae with EC50 of 157 p.p.m, reveals an antifeedant effect against Trichoplusia ni larva with a DC50 of 10.8 μg/cm2[3].
Cymarin (2 mg/kg, i.p., twice a week for 3 weeks) inhibits tumor growth, eliminates TRA-1-60 cells and decreases chemoresistance in SW1990 xenografted nude mice[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Trichoplusia ni[3]
Dosage: 1000 p.p.m.
Administration: p.o. for 10 days
Result: Inhibited growth and revealed a feeding deterrent to T.ni.
Animal Model: Luciferase labeled SW1990 xenograft in nude mice[4]
Dosage: 2 mg/kg
Administration: i.p., twice a week for 3 weeks
Result: Inhibited tumor growth.
Molecular Weight

548.66

Formula

C30H44O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C[C@@]12[C@]3([H])[C@](CC[C@@]1(C[C@@H](O[C@@]4([H])C[C@@H]([C@H](O)[C@@H](C)O4)OC)CC2)O)([H])[C@@]5([C@@](C)([C@@H](C(CO6)=CC6=O)CC5)CC3)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 97.82%

SDS (644 KB)

COA (255 KB)

Handling Instructions (2659 KB)
References
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Cymarin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cymarin508-77-0ParasitePotassium ChannelKcsApancreatic cancerbreast cancerantifeedantMCF-7SW1990Trichoplusia niInhibitorinhibitorinhibit

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