2. Immunology/Inflammation Apoptosis
  3. PD-1/PD-L1 Apoptosis
  4. [D-Leu-4]-OB3

[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

[D-Leu-4]-OB3 Chemical Structure

[D-Leu-4]-OB3 Chemical Structure

CAS No. : 289056-32-2

Size Price Stock Quantity
5 mg USD 50 In-stock
10 mg USD 70 In-stock
25 mg USD 138 In-stock
50 mg USD 220 In-stock
100 mg USD 350 In-stock
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Based on 1 publication(s) in Google Scholar

[D-Leu-4]-OB3 Related Antibodies

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Description

[D-Leu-4]-OB3 inhibits expressions of pro-inflammatory, proliferative and metastatic genes and PD-L1 expression. [D-Leu-4]-OB3 stimulates expression of pro-apoptotic genes[1].

Molecular Weight

734.82

Formula

C29H50N8O12S
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Cys-Ser-{D-Leu}-Pro-Gln-Thr
Sequence Shortening

SCS-{D-Leu}-PQT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (68.04 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3609 mL 6.8044 mL 13.6088 mL
5 mM 0.2722 mL 1.3609 mL 2.7218 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3609 mL 6.8044 mL 13.6088 mL 34.0219 mL
5 mM 0.2722 mL 1.3609 mL 2.7218 mL 6.8044 mL
10 mM 0.1361 mL 0.6804 mL 1.3609 mL 3.4022 mL
15 mM 0.0907 mL 0.4536 mL 0.9073 mL 2.2681 mL
20 mM 0.0680 mL 0.3402 mL 0.6804 mL 1.7011 mL
25 mM 0.0544 mL 0.2722 mL 0.5444 mL 1.3609 mL
30 mM 0.0454 mL 0.2268 mL 0.4536 mL 1.1341 mL
40 mM 0.0340 mL 0.1701 mL 0.3402 mL 0.8505 mL
50 mM 0.0272 mL 0.1361 mL 0.2722 mL 0.6804 mL
60 mM 0.0227 mL 0.1134 mL 0.2268 mL 0.5670 mL
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[D-Leu-4]-OB3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[D-Leu-4]-OB3289056-32-2PD-1/PD-L1ApoptosisPD-1/Programmed death-ligand 1ObesityLeptinOB3 peptideInflammationHepatocellular carcinoma cellsInhibitorinhibitorinhibit

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