D-threo-PDMP hydrochloride

Cat. No.: HY-116392F Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

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D-threo-PDMP hydrochloride is a glucosylceramide (GlcCer) synthase inhibitor that inhibits glucosylceramide (GlcCer) and lactosylceramide (LacCer) levels in B16 melanoma cells. D-threo-PDMP hydrochloride lacks reactivity to the other two surface antigens anti-melanoma monoclonal antibodies M562 and M622 and the major histocompatibility antigen anti-H-2KbDb monoclonal antibody, so it is specific for B16 melanoma sex.

For research use only. We do not sell to patients.

D-threo-PDMP hydrochloride Chemical Structure

CAS No. : 139889-62-6

Size	Price	Stock	Quantity
1 mg	USD 275	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 695	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of D-threo-PDMP hydrochloride:

(−)-L-threo-PDMP hydrochloride Get quote
DL-threo-PDMP hydrochloride Get quote
PDMP hydrochloride Get quote
D,L-erythro-PDMP Get quote
D,L-erythro-PDMP hydrochloride Get quote
D-threo-PDMP Get quote

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

427.02

Formula

C₂₃H₃₉ClN₂O₃

CAS No.

139889-62-6

Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCC(N[C@H](CN1CCOCC1)[C@H](O)C2=CC=CC=C2)=O.Cl[H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

Ethanol : 50 mg/mL (117.09 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3418 mL	11.7091 mL	23.4181 mL
5 mM	0.4684 mL	2.3418 mL	4.6836 mL
10 mM	0.2342 mL	1.1709 mL	2.3418 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% EtOH 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 1.25 mg/mL (2.93 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% EtOH 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 1.25 mg/mL (2.93 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% EtOH 90% Corn Oil
Solubility: ≥ 1.25 mg/mL (2.93 mM); Clear solution

This protocol yields a clear solution of ≥ 1.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL EtOH stock solution (12.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (246 KB)

Handling Instructions (2659 KB)

References

[1]. Inokuchi J, et al. Effects of D-threo-PDMP, an inhibitor of glucosylceramide synthetase, on expression of cell surface glycolipid antigen and binding to adhesive proteins by B16 melanoma cells. J Cell Physiol. 1989 Dec;141(3):573-83. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Ethanol	1 mM	2.3418 mL	11.7091 mL	23.4181 mL	58.5453 mL
	5 mM	0.4684 mL	2.3418 mL	4.6836 mL	11.7091 mL
	10 mM	0.2342 mL	1.1709 mL	2.3418 mL	5.8545 mL
	15 mM	0.1561 mL	0.7806 mL	1.5612 mL	3.9030 mL
	20 mM	0.1171 mL	0.5855 mL	1.1709 mL	2.9273 mL
	25 mM	0.0937 mL	0.4684 mL	0.9367 mL	2.3418 mL
	30 mM	0.0781 mL	0.3903 mL	0.7806 mL	1.9515 mL
	40 mM	0.0585 mL	0.2927 mL	0.5855 mL	1.4636 mL
	50 mM	0.0468 mL	0.2342 mL	0.4684 mL	1.1709 mL
	60 mM	0.0390 mL	0.1952 mL	0.3903 mL	0.9758 mL
	80 mM	0.0293 mL	0.1464 mL	0.2927 mL	0.7318 mL
	100 mM	0.0234 mL	0.1171 mL	0.2342 mL	0.5855 mL