2. Apoptosis Anti-infection
  3. Apoptosis Antibiotic
  4. Dacarbazine citrate

Dacarbazine citrate  (Synonyms: Imidazole Carboxamide citrate)

Cat. No.: HY-B0078A
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Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma.

For research use only. We do not sell to patients.

Dacarbazine citrate Chemical Structure

Dacarbazine citrate Chemical Structure

CAS No. : 64038-56-8

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Dacarbazine citrate Related Antibodies

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Description

Dacarbazine citrate is a cell cycle nonspecific antineoplastic alkylating agent. Dacarbazine citrate inhibits T and B lymphoblastic response, with IC50 values of 50 and 10 μg/mL, respectively. Dacarbazine Citrate can be used for the research of apoptosis and various cancers such as metastatic malignant melanoma[1][2].

In Vitro

Dacarbazine citrate has less pronounced inhibition of mitogenesis with IC50 values of 50 and 10 μg/mL for T and B cells, respectively[2].
Dacarbazine citrate (30 μM, 0-14 min) evokes a concentration-dependent calcium response in hTRPA1-HEK293 cells with an EC50 value of 23 μM and selectively activates the human TRPA1 channel[3].
Dacarbazine citrate (100-10,000 μM, 24 h) has cytotoxic action on B16-F10 melanoma cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dacarbazine citrate Related Antibodies

Cell Viability Assay[3]

Cell Line: B16-F10 cell
Concentration: 100-10,000 μM
Incubation Time: 24 h
Result: Reduced cell viability to 3,000 and 10,000 uM, with an inhibition percentage of 62 ± 2% after 24 h of incubation.
In Vivo

Dacarbazine citrate (1 mg/kg, i.p.) evokes a concentration-dependent calcium response and the maximum calcium response with an EC50 value of 16 μM in a subset of cells of cultured mouse DRG neurons and excites TRPA1 in rodent sensory neurons[3].
Dacarbazine citrate (1 mg/kg, i.p.; 1, 3, 5 and 7 days for chronic pain or 1 mg/kg, i.p. for acute treatment) induces mechanical and cold allodynia in mice[3].
Dacarbazine citrate-induced nociception can be reduced by TRPA1-deficient mice and antisense oligonucleotide for the TRPA1 receptor[3].
Dacarbazine citrate-induced chronic nociception can be reduced by selective TRPA1 receptor antagonists and antioxidants[3].
Dacarbazine citrate-induced nociception can be resisted by RPA1 antagonist or an antioxidant in a tumor-associated cancer pain model[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6, Trpa1+/+ or Trpa1−/− mice[3]
Dosage: 1 mg/kg
Administration: 1 mg/kg, i.p. (for acute treatment); 1 mg/kg, i.p.; 1, 3, 5 and 7 days (for chronic pain)
Result: Caused mechanical allodynia with acute or repeated administration.
Clinical Trial
Molecular Weight

374.31

Formula

C12H18N6O8
CAS No.
SMILES

O=C(C1=C(/N=N/N(C)C)NC=N1)N.O=C(CC(C(O)=O)(O)CC(O)=O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Dacarbazine citrate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dacarbazine64038-56-8Imidazole CarboxamideApoptosisAntibioticcell cycleantineoplasticalkylating agentT lymphoblasticB lymphoblasticmetastatic malignant melanomacancerInhibitorinhibitorinhibit

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