2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. DAM-IN-1

DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor, IC50: 48 μM. DMA-IN-1 inhibits Caulobacter growth with an MIC of 35 μM.

For research use only. We do not sell to patients.

DAM-IN-1 Chemical Structure

DAM-IN-1 Chemical Structure

CAS No. : 935279-95-1

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Based on 1 publication(s) in Google Scholar

DAM-IN-1 Related Antibodies

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Description

DMA-IN-1 is a DNA adenine methyltransferase (DAM) inhibitor, IC50: 48 μM. DMA-IN-1 inhibits Caulobacter growth with an MIC of 35 μM[1].

IC50 & Target

IC50: 48 μM (DNA adenine methyltransferase, DAM)[1]
Molecular Weight

287.31

Formula

C16H17NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCOC(=O)C1C2CC=CC2C3=C(N1)C=CC(=C3)C(=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (348.06 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.4806 mL 17.4028 mL 34.8056 mL
5 mM 0.6961 mL 3.4806 mL 6.9611 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.4806 mL 17.4028 mL 34.8056 mL 87.0140 mL
5 mM 0.6961 mL 3.4806 mL 6.9611 mL 17.4028 mL
10 mM 0.3481 mL 1.7403 mL 3.4806 mL 8.7014 mL
15 mM 0.2320 mL 1.1602 mL 2.3204 mL 5.8009 mL
20 mM 0.1740 mL 0.8701 mL 1.7403 mL 4.3507 mL
25 mM 0.1392 mL 0.6961 mL 1.3922 mL 3.4806 mL
30 mM 0.1160 mL 0.5801 mL 1.1602 mL 2.9005 mL
40 mM 0.0870 mL 0.4351 mL 0.8701 mL 2.1754 mL
50 mM 0.0696 mL 0.3481 mL 0.6961 mL 1.7403 mL
60 mM 0.0580 mL 0.2900 mL 0.5801 mL 1.4502 mL
80 mM 0.0435 mL 0.2175 mL 0.4351 mL 1.0877 mL
100 mM 0.0348 mL 0.1740 mL 0.3481 mL 0.8701 mL
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DAM-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DAM-IN-1935279-95-1DNA/RNA SynthesisDNA adenine methyltransferaseinhibitorsbinding assayscell cycle–regulated methyltransferaseInhibitorinhibitorinhibit

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