Dapiprazole

Cat. No.: HY-A0142: FAQs
Data Sheet Handling Instructions

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Dapiprazole is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole suppresses the opioid withdrawal symptoms. Dapiprazole is also used as eye drops for reversing mydriasis.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Dapiprazole hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Dapiprazole Chemical Structure

CAS No. : 72822-12-9

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Other In-stock Forms of Dapiprazole:

Dapiprazole hydrochloride

Other Forms of Dapiprazole:

Dapiprazole hydrochloride In-stock

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

α1-adrenergic receptor

In Vivo

Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model^[1]
Dosage:	5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
Administration:	Intraperitoneal injection or intracerebroventricular administration, once
Result:	Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.

Molecular Weight

325.45

Formula

C₁₉H₂₇N₅

CAS No.

72822-12-9

SMILES

CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7. [Content Brief]

[2]. Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3, 138. [Content Brief]

[3]. Hou RH, et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007 Nov;195(1):41-59. [Content Brief]

Dapiprazole Related Classifications

Endocrinology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Dapiprazole72822-12-9Adrenergic ReceptorBeta Receptoropioid withdrawalmydriasisInhibitorinhibitorinhibit

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