Dapiprazole hydrochloride

Name: Dapiprazole hydrochloride
Brand: MedChemExpress
SKU: HY-A0142A
Rating: 4.5 (1 reviews)

Cat. No.: HY-A0142A Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Dapiprazole hydrochloride is a potent, selective and orally active alpha-1 adrenoceptor antagonist. Dapiprazole hydrochloride suppresses the opioid withdrawal symptoms. Dapiprazole hydrochloride is also used as eye drops for reversing mydriasis.

For research use only. We do not sell to patients.

Dapiprazole hydrochloride Chemical Structure

CAS No. : 72822-13-0

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 39	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 39	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 35	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 55	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 110	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 168	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 250	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Dapiprazole hydrochloride:

Dapiprazole Get quote

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•Related Screening Libraries:

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View All Adrenergic Receptor Isoform Specific Products:

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

α1-adrenergic receptor

In Vivo

Dapiprazole hydrochloride (0-10 mg/kg or 0-3 mg/mice; i.p. or i.c.v.; once) reduces the overall severity of the opiate withdrawal symptoms in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Swiss Albino male CD-1 mice weighing 20 -25 g, acute dependence model^[1]
Dosage:	5, 7.5 and 10 mg/kg (i.p.) or 0.5, 1 and 3 mg/mice (i.c.v.), once
Administration:	Intraperitoneal injection or intracerebroventricular administration, once
Result:	Decreased jumping behavior, head shakes and paw shakes when administered just before naloxone.

Molecular Weight

361.91

Formula

C₁₉H₂₈ClN₅

CAS No.

72822-13-0

Appearance

Solid

Color

White to off-white

SMILES

CC1=CC=CC=C1N2CCN(CCC3=NN=C4CCCCN43)CC2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (276.31 mM; Need ultrasonic)

DMSO : 12.5 mg/mL (34.54 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7631 mL	13.8156 mL	27.6312 mL
5 mM	0.5526 mL	2.7631 mL	5.5262 mL
10 mM	0.2763 mL	1.3816 mL	2.7631 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 50 mg/mL (138.16 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (253 KB) HNMR (264 KB) LCMS (268 KB)

Handling Instructions (2659 KB)

References

[1]. Valeri P, et al. Effects of dapiprazole, clonidine and yohimbine on the development of dependence and withdrawal behaviour in mice. Drug Alcohol Depend. 1989 Jan;23(1):73-7. [Content Brief]

[2]. Allinson RW, et al. Reversal of mydriasis by dapiprazole. Ann Ophthalmol. 1990 Apr;22(4):131-3, 138. [Content Brief]

[3]. Hou RH, et al. Arousal and the pupil: why diazepam-induced sedation is not accompanied by miosis. Psychopharmacology (Berl). 2007 Nov;195(1):41-59. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.7631 mL	13.8156 mL	27.6312 mL	69.0779 mL
	5 mM	0.5526 mL	2.7631 mL	5.5262 mL	13.8156 mL
	10 mM	0.2763 mL	1.3816 mL	2.7631 mL	6.9078 mL
	15 mM	0.1842 mL	0.9210 mL	1.8421 mL	4.6052 mL
	20 mM	0.1382 mL	0.6908 mL	1.3816 mL	3.4539 mL
	25 mM	0.1105 mL	0.5526 mL	1.1052 mL	2.7631 mL
	30 mM	0.0921 mL	0.4605 mL	0.9210 mL	2.3026 mL
H₂O	40 mM	0.0691 mL	0.3454 mL	0.6908 mL	1.7269 mL
	50 mM	0.0553 mL	0.2763 mL	0.5526 mL	1.3816 mL
	60 mM	0.0461 mL	0.2303 mL	0.4605 mL	1.1513 mL
	80 mM	0.0345 mL	0.1727 mL	0.3454 mL	0.8635 mL
	100 mM	0.0276 mL	0.1382 mL	0.2763 mL	0.6908 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.