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DB0662 is a compound for kinase-targeted protein degradation and can be used in studies of diseases mediated by abnormal kinase activity, as well as for the identification of degradable kinases and optimal kinases.

For research use only. We do not sell to patients.

DB0662 Chemical Structure

DB0662 Chemical Structure

CAS No. : 2769753-51-5

Size Price Stock Quantity
5 mg USD 750 In-stock
10 mg USD 1280 In-stock
25 mg USD 2400 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DB0662 is a compound for kinase-targeted protein degradation and can be used in studies of diseases mediated by abnormal kinase activity, as well as for the identification of degradable kinases and optimal kinases[1].

Molecular Weight

931.92

Formula

C47H44F3N11O7
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(N3C(N(C)C4=NC(NC5=CN=C(N6CCN(CCCOC7=CC=CC(C(N8C9C(NC(CC9)=O)=O)=O)=C7C8=O)CC6)C=C5)=NC=C4C3)=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (53.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0731 mL 5.3653 mL 10.7305 mL
5 mM 0.2146 mL 1.0731 mL 2.1461 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0731 mL 5.3653 mL 10.7305 mL 26.8263 mL
5 mM 0.2146 mL 1.0731 mL 2.1461 mL 5.3653 mL
10 mM 0.1073 mL 0.5365 mL 1.0731 mL 2.6826 mL
15 mM 0.0715 mL 0.3577 mL 0.7154 mL 1.7884 mL
20 mM 0.0537 mL 0.2683 mL 0.5365 mL 1.3413 mL
25 mM 0.0429 mL 0.2146 mL 0.4292 mL 1.0731 mL
30 mM 0.0358 mL 0.1788 mL 0.3577 mL 0.8942 mL
40 mM 0.0268 mL 0.1341 mL 0.2683 mL 0.6707 mL
50 mM 0.0215 mL 0.1073 mL 0.2146 mL 0.5365 mL
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DB0662 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DB06622769753-51-5DB 0662DB-0662Otherskinase-targeted proteindegradable kinasesoptimal kinasesabnormal kinaseInhibitorinhibitorinhibit

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