Desoxypeganine hydrochloride (Synonyms: Deoxypeganine hydrochloride; Deoxyvasicine hydrochloride)

Cat. No.: HY-108048A: FAQs
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Desoxypeganine (Deoxypeganine) hydrochloride, an alkaloid, is a potent and orally active cholinesterase (BChE and AChE) and selective MAO-A inhibitor, with IC₅₀ values of 2, 17, and 2 μM, respectively. Desoxypeganine hydrochloride can be used for alcohol abuse research.

For research use only. We do not sell to patients.

Desoxypeganine hydrochloride Chemical Structure

CAS No. : 61939-05-7

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Other Forms of Desoxypeganine hydrochloride:

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

BChE

2 μM (IC₅₀)

AChE

17 μM (IC₅₀)

MAO-A

2 μM (IC₅₀)

In Vivo

Desoxypeganine hydrochloride (10-30 mg/kg, gavage, once daily for 16 days) reduced ethanol intake and ethanol preference dose-dependently^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female Alko alcohol (AA) rats (Thirty eight adult)^[1]
Dosage:	10, 20, 30 mg/kg
Administration:	Gavage, once daily in a volume of 10 ml/kg at 6:00 pm, for 16 days
Result:	Abolished ethanol preference.

Molecular Weight

208.69

Formula

C₁₁H₁₃ClN₂

CAS No.

61939-05-7

SMILES

[H]Cl.C12=NC3=C(C=CC=C3)CN1CCC2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Doetkotte R, et al. Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine. Eur J Pharmacol. 2005 Oct 17;522(1-3):72-7. [Content Brief]

[2]. Zheng XY, et al. Acetylcholinesterase inhibitive activity-guided isolation of two new alkaloids from seeds of Peganum nigellastrum Bunge by an in vitro TLC- bioautographic assay. Arch Pharm Res. 2009 Sep;32(9):1245-51. [Content Brief]

Desoxypeganine hydrochloride Related Classifications

Neurological Disease

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
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The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Desoxypeganine61939-05-7DeoxypeganineDeoxyvasicineCholinesterase (ChE)Monoamine OxidaseMAOPeganum harmala L.butyrylcholinesteraseacetylcholinesteraseAlko alcoholalcohol abuseInhibitorinhibitorinhibit

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