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  6. Dextran sulfate sodium salt (MW 35000-50000)

Dextran sulfate sodium salt (MW 35000-50000)  (Synonyms: DSS (MW 35000-50000); DXS (MW 35000-50000))

Cat. No.: HY-116282C
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Dextran sulfate sodium salt (MW 35000-50000) is a polymer of anhydroglucose and is a potent inducer of colitis. Dextran sulfate sodium salt (MW 35000-50000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium. Dextran sulfate sodium salt (MW 35000-50000) also inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells. Dextran sulfate sodium salt (MW 35000-50000) is also used to bind to insulin, encapsulate it in gold nanoparticles, and serve as an insulin carrier to bind to insulin receptors to achieve the purpose of slowly releasing insulin and prolonging insulin activity.

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Dextran sulfate sodium salt (MW 35000-50000) Chemical Structure

Dextran sulfate sodium salt (MW 35000-50000) Chemical Structure

CAS No. : 9011-18-1

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Other Forms of Dextran sulfate sodium salt (MW 35000-50000):

Dextran sulfate sodium salt (MW 35000-50000) Related Antibodies

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2 Publications Citing Use of MCE Dextran sulfate sodium salt (MW 35000-50000)

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Description

Dextran sulfate sodium salt (MW 35000-50000) is a polymer of anhydroglucose and is a potent inducer of colitis. Dextran sulfate sodium salt (MW 35000-50000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium. Dextran sulfate sodium salt (MW 35000-50000) also inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells. Dextran sulfate sodium salt (MW 35000-50000) is also used to bind to insulin, encapsulate it in gold nanoparticles, and serve as an insulin carrier to bind to insulin receptors to achieve the purpose of slowly releasing insulin and prolonging insulin activity[1][2][3][4][5].

In Vitro

Dextran sulfate (average molecular weight=35,000-45,000 Da, AuNPs@Dextran) can be used to target insulin through molecular recognition with a dissociation constant of approximately 5.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran sulfate sodium salt (MW 35000-50000) Related Antibodies
In Vivo

Induction of Colitis[2][3][4][5]
Background
Adding dextran sulfate sodium (DSS) to the drinking water of mice or rats can induce colon epithelial damage and a strong inflammatory response that lasts for several days, inducing colitis [4]. Clinical manifestations of colitis typically include watery diarrhea, hematochezia, and weight loss. The induced symptoms are very similar to human ulcerative colitis (UC) and can be used to study the occurrence and development mechanisms of acute and chronic colitis. Models can be created in many species of animals: mice, rats, zebrafish, pigs, fruit flies, etc.
Specific Mmodeling Methods
Mice: Male C57BL/6J mice • 9-week-old
Administration: 1% w/v • po (added in drinking water) • administered in 7 days cycles
Mice: Male SPF-grade C57BL/6 mice • 6-8 weeks old
Administration: 2.8% w/v • po (added in drinking water) • administered in 7 days cycles
Rat: Sprague-Dawley male rats • 7-9 weeks old • 170-200 g
Administration: 4.5%-6.0% w/v • po (added in drinking water) • administered in 7 days cycles
Note
1. Mice were administrated in cycles, with each cycle lasting 7 days and 10 days between cycles (normal drinking water is provided during this period). Acute colitis can be induced for one cycle, and chronic colitis can be treated repeatedly for three cycles.
2. The dosage of the acute phase model of the mouse model is usually 3-5% (w/v), and the dosage of the chronic model is usually 1-3% (w/v). The specific experimental needs and animals The applicable concentration of the type should continue to be explored.
3. Use sterile water to prepare DSS drinking water, and then filter it with a 0.22 μm filter membrane; or use autoclaved sterile water to prepare it.

Modeling Success Index
Clinical symptoms: weight loss; increased DAI (disease activity index score); tissue edema, congestion, and inflammation. (DAI mainly evaluates and scores from three aspects, namely body weight, fecal viscosity, fecal occult blood, etc.)
Colon changes: The length of the colon is shortened, and inflammatory cell infiltration is obvious in colon tissue sections. Increased, even ulcer formation.
Changes at the cellular level: Goblet cells fall off, epithelial cells and goblet cells disappear, glandular crypt openings expand, crypt abscesses occur, and the muscle layer thickens and detaches.
Correlated Product(s): Oxazolone (HY-126360)
Opposite Product(s): Carpalasionin (HY-N7533)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

35000-45000

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran sulfate sodium salt (MW 35000-50000)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

COA (241 KB)

Handling Instructions (2659 KB)
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Dextran sulfate sodium salt (MW 35000-50000) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dextran sulfate sodium salt (MW 35000-50000)9011-18-1DSS (MW 35000-50000) DXS (MW 35000-50000)HIVApoptosisHuman immunodeficiency viruscolitishuman immunodeficiency virusInhibitorinhibitorinhibit

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