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  6. Dextran sulfate sodium salt (MW 35000-45000)

Dextran sulfate sodium salt (MW 35000-45000)  (Synonyms: DSS (MW 35000-45000); DXS (MW 35000-45000))

Cat. No.: HY-116282C
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Dextran sulfate sodium salt (MW 35000-45000) is a polymer of anhydroglucose and is a potent inducer of colitis. Dextran sulfate sodium salt (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium. Dextran sulfate sodium salt (MW 35000-45000) also inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells. Dextran sulfate sodium salt (MW 35000-45000) is also used to bind to insulin, encapsulate it in gold nanoparticles, and serve as an insulin carrier to bind to insulin receptors to achieve the purpose of slowly releasing insulin and prolonging insulin activity.

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Dextran sulfate sodium salt (MW 35000-45000) Chemical Structure

Dextran sulfate sodium salt (MW 35000-45000) Chemical Structure

CAS No. : 9011-18-1

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Based on 2 publication(s) in Google Scholar

Other Forms of Dextran sulfate sodium salt (MW 35000-45000):

Dextran sulfate sodium salt (MW 35000-45000) Related Antibodies

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2 Publications Citing Use of MCE Dextran sulfate sodium salt (MW 35000-45000)

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Description

Dextran sulfate sodium salt (MW 35000-45000) is a polymer of anhydroglucose and is a potent inducer of colitis. Dextran sulfate sodium salt (MW 35000-45000) may be related to macrophage dysfunction, intestinal flora dysbiosis, and is particularly toxic to the colonic epithelium. Dextran sulfate sodium salt (MW 35000-45000) also inhibits human immunodeficiency virus replication by preventing viral adsorption to host cells. Dextran sulfate sodium salt (MW 35000-45000) is also used to bind to insulin, encapsulate it in gold nanoparticles, and serve as an insulin carrier to bind to insulin receptors to achieve the purpose of slowly releasing insulin and prolonging insulin activity[1][2][3][4][5].

In Vitro

Dextran sulfate (average molecular weight=35,000-45,000 Da, AuNPs@Dextran) can be used to target insulin through molecular recognition with a dissociation constant of approximately 5.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dextran sulfate sodium salt (MW 35000-45000) Related Antibodies
In Vivo

Dextran sulfate sodium salt (MW 35000-45000) can be used to induce acute/chronic colitis and colitis-associated colon cancer models[6][7][8][9][10].

1. Induction of acute colitis model[6][7][8]
Background
DSS disrupts the intestinal mucosal barrier, activates immune cells, and triggers oxidative stress responses. These factors collectively lead to acute inflammation of the intestinal mucosa.
Specific Mmodeling Methods
Mice: C57BL/6 • 6-12 weeks old • 18-22 g
Administration: 1.75%-5% (w/v) DSS in drinking water • 7 days
Note
(1) It is recommended to replace the drinking water containing DSS every 1-2 days. The water intake can be calculated according to 7-10 mL per day for mice and 11 mL/100 g of body weight per day for rats. Ensure that there is no blockage or leakage in the water bottle.
(2) Record the water intake, body weight, and disease phenotype every day.
(3) The concentration of the DSS solution, the species and strain of the animals may all affect the effect of model establishment. The optimal age range for successfully and easily repeating the DSS colitis is 6 to 8 weeks, and male mice may be more sensitive than female mice.
(4) In order to reduce the difference in water intake and observe the progress of model establishment more clearly, it is recommended to house 2-3 animals in each cage, and no more than 5 animals per cage.
Modeling Indicators
Phenotypic observation: body weight reduction within the range of 10%-20%, diarrhea, bloody stools, and a significant shortening of the colon.
Histological changes (HE staining in the colon tissue): mucosal damage, crypt structure destruction, goblet cells shedding/disappearance, granulocyte infiltration.
Correlated Product(s): /
Opposite Product(s): P-2281 (HY-118704)；Biochanin A (HY-14595)
2. Induction of chronic colitis model[9]
Background
The continuous effect of DSS repeatedly damages the intestinal mucosa, leading to an imbalance in immune regulation and a dysbiosis of the intestinal microbiota. This results in the inflammation lingering and failing to heal, thus giving rise to chronic colitis.
Specific Mmodeling Methods
Mice: C57BL/6 • 6-12 weeks old • 18-22 g
Administration: 2%-3% (w/v) DSS in drinking water (A cycle consists of 7 days of DSS in the drinking water and 14 days with normal water, and this cycle is repeated three times.)
Modeling Indicators
Phenotypic observation: body weight and spleen weight reduction, diarrhea, bloody stools, rectal bleeding, and a significant shortening of the colon.
Histological changes (HE staining in the colon tissue): mucosal damage, crypt structure destruction, goblet cells shedding/disappearance, inflammatory cells infiltration.
Correlated Product(s): /
Opposite Product(s): /
3. Induction of colitis-associated colon cancer model[9][10]
Background
The long-term intestinal inflammatory environment induced by DSS generates a large number of inflammatory factors and oxidative stress products, which can damage the DNA of intestinal mucosal cells, leading to gene mutations. At the same time, it disrupts the balance between cell proliferation and apoptosis, and create a microenvironment conducive to tumor growth, thus triggering colon cancer.
Specific Mmodeling Methods
Mice: C57BL/6 • 6-12 weeks old • 18-22 g
Administration: Intraperitoneally inject the carcinogen Azoxymethane (AOM, HY-111375) at a dose of 10 mg/kg. One week later, provide drinking water containing 2%-2.5% (w/v) of DSS (A cycle consists of 7 days with DSS in the drinking water and 14 days with normal water, and this cycle is repeated three times).
Modeling Indicators
Phenotypic observation: body weight reduction, diarrhea, bloody stools, loose stools, and a significant shortening and thickening of the colon.
Molecular levels changes: activation of NF-κB and STAT3.
Histological changes (HE staining in the colon tissue): mucosal damage, crypt structure destruction, goblet cells shedding/disappearance, inflammatory cells infiltration.
Correlated Product(s): Triclosan (HY-B1119)
Opposite Product(s): /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

35000-45000

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[Dextran sulfate sodium salt (MW 35000-45000)]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 100 mg/mL (Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL; Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
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Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

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COA (241 KB)

Handling Instructions (2659 KB)
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Dextran sulfate sodium salt (MW 35000-45000) Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dextran sulfate sodium salt (MW 35000-45000)9011-18-1DSS (MW 35000-45000) DXS (MW 35000-45000)HIVApoptosisHuman immunodeficiency viruscolitishuman immunodeficiency virusInhibitorinhibitorinhibit

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