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DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity.

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DI-82 Chemical Structure

DI-82 Chemical Structure

CAS No. : 1638148-50-1

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Based on 1 publication(s) in Google Scholar

DI-82 Related Antibodies

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  • Purity & Documentation

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Description

DI-82 is a potent deoxycytidine kinase (dCK) inhibitor with an IC50app of 27.8 nM and Kiapp of 9.2 nM. DI-82 has antitumor activity[1].

IC50 & Target

IC50app: 27.8 nM (dCK)[1]
Kiapp: 9.2 nM (dCK)[1]
Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
3.7 nM
Compound: 12R
Inhibition of dCK in human CCRF-CEM cells assessed as inhibition of [3H]-dC uptake by scintillation counting analysis
Inhibition of dCK in human CCRF-CEM cells assessed as inhibition of [3H]-dC uptake by scintillation counting analysis
[PMID: 25341194]
In Vitro

DI-82 (compound 12R) has an IC50 of 3.7 nM in CCRF-CEM acute lymphoblastic leukemia cells[1].
DI-82 (1 μM) has a NADPH-dependent CLint of 22.7 μL/min•mg and a NADPH-dependent T1/2 of 102 mins in a standard microsomal liver clearance assay[1].
DI-82 (200 μM) completely blunts the ability of decitabine to bind human thymidylate synthase (TS)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DI-82 Related Antibodies
Molecular Weight

510.65

Formula

C20H26N6O4S3
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

NC1=NC(S[C@H](C)C(N=C2C(C=C3OCCNS(=O)(C)=O)=CC=C3OC)=C(S2)C)=NC(N)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (234.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9583 mL 9.7914 mL 19.5829 mL
5 mM 0.3917 mL 1.9583 mL 3.9166 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9583 mL 9.7914 mL 19.5829 mL 48.9572 mL
5 mM 0.3917 mL 1.9583 mL 3.9166 mL 9.7914 mL
10 mM 0.1958 mL 0.9791 mL 1.9583 mL 4.8957 mL
15 mM 0.1306 mL 0.6528 mL 1.3055 mL 3.2638 mL
20 mM 0.0979 mL 0.4896 mL 0.9791 mL 2.4479 mL
25 mM 0.0783 mL 0.3917 mL 0.7833 mL 1.9583 mL
30 mM 0.0653 mL 0.3264 mL 0.6528 mL 1.6319 mL
40 mM 0.0490 mL 0.2448 mL 0.4896 mL 1.2239 mL
50 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.9791 mL
60 mM 0.0326 mL 0.1632 mL 0.3264 mL 0.8160 mL
80 mM 0.0245 mL 0.1224 mL 0.2448 mL 0.6120 mL
100 mM 0.0196 mL 0.0979 mL 0.1958 mL 0.4896 mL
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DI-82 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DI-821638148-50-1DI82DI 82OthersdeoxycytidinekinasedCKantitumorCCRF-CEMacutelymphoblasticleukemiaNADPHInhibitorinhibitorinhibit

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