Diamino lipid DAL4 

Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity^[1].

Diamino lipid DAL4 (DAL4-LNP) effectively delivers different mRNAs in vitro to tumor cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Diamino lipid DAL4 (DAL4-LNP) loaded with IL-12 mRNA (intratumoral injection) is most potent in inhibiting B16F10 melanoma tumor growth compared to IL-27 or GM-CSF mRNAs in monotherapy^[1].
Diamino lipid DAL4 loaded with IL-12 mRNA and IL-27 mRNA (intratumoral injection) shows synergistic effect in suppressing tumor growth without causing systematic toxicity^[1].
And also Diamino lipid DAL4 induces robust infiltration of immune effector cells, including IFN-γ and TNF-α producing natural killer cells (NK) and CD8⁺ T cells into tumors^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

844.17

C₅₂H₉₉BFN₃O₃

2939000-43-6

CCCCCCCCCCCCN(CCCN(CCCCCC(NCC1=C(B(O)O)C=C(F)C=C1)=O)CCCCCCCCCCCC)CCCCCCCCCCCC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Liu JQ, et al. Intratumoral delivery of IL-12 and IL-27 mRNA using lipid nanoparticles for cancer immunotherapy. J Control Release. 2022 May;345:306-313.  [Content Brief]