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  3. Diamino lipid DAL4

Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity.

For research use only. We do not sell to patients.

Diamino lipid DAL4 Chemical Structure

Diamino lipid DAL4 Chemical Structure

CAS No. : 2939000-43-6

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Description

Diamino lipid DAL4 is diamino lipid for the preparation of lipid nanoparticles (LNPs) encapsulated with mRNAs encoding cytokines including IL-12, IL-27 and GM-CSF. Diamino lipid DAL4 delivers mRNA to tumor cells to exert anti-tumor activity[1].

In Vitro

Diamino lipid DAL4 (DAL4-LNP) effectively delivers different mRNAs in vitro to tumor cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Diamino lipid DAL4 (DAL4-LNP) loaded with IL-12 mRNA (intratumoral injection) is most potent in inhibiting B16F10 melanoma tumor growth compared to IL-27 or GM-CSF mRNAs in monotherapy[1].
Diamino lipid DAL4 loaded with IL-12 mRNA and IL-27 mRNA (intratumoral injection) shows synergistic effect in suppressing tumor growth without causing systematic toxicity[1].
And also Diamino lipid DAL4 induces robust infiltration of immune effector cells, including IFN-γ and TNF-α producing natural killer cells (NK) and CD8+ T cells into tumors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

844.17

Formula

C52H99BFN3O3

CAS No.
SMILES

CCCCCCCCCCCCN(CCCN(CCCCCC(NCC1=C(B(O)O)C=C(F)C=C1)=O)CCCCCCCCCCCC)CCCCCCCCCCCC

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Diamino lipid DAL4
Cat. No.:
HY-151508
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