2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. Diorcinol

Diorcinol is a potent SHP1 inhibitor with an IC50 value of 0.96 μM. Diorcinol can be isolated from Aspergillus sydowii. Diorcinol has good blood-brain barrier penetration and can be used for diabetes research.

For research use only. We do not sell to patients.

Diorcinol Chemical Structure

Diorcinol Chemical Structure

CAS No. : 20282-75-1

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Based on 1 publication(s) in Google Scholar

Diorcinol Related Antibodies

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  • Purity & Documentation

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Description

Diorcinol is a potent SHP1 inhibitor with an IC50 value of 0.96 μM. Diorcinol can be isolated from Aspergillus sydowii. Diorcinol has good blood-brain barrier penetration and can be used for diabetes research[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
31.6 μM
Compound: 52
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human A549 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
HL-60 IC50
> 10 μM
Compound: 14
Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human HL60 cells assessed as inhibition of cell viability by MTT assay
[PMID: 23527875]
K562 IC50
> 10 μM
Compound: 14
Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay
Cytotoxicity against human K562 cells assessed as inhibition of cell viability by MTT assay
[PMID: 23527875]
NCI-H157 IC50
20.2 μM
Compound: 52
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
Antiproliferative activity against human NCI-H157 cells assessed as reduction in cell viability measured after 72 hrs by sulforhodamine B assay
[PMID: 33691166]
Neutrophil IC50
> 10 μg/mL
Compound: 11
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced elastase release after 5 mins by spectrophotometric analysis
[PMID: 23647825]
Neutrophil IC50
12.21 μM
Compound: 11
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide generation after 5 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLP/CB-induced superoxide generation after 5 mins by spectrophotometric analysis
[PMID: 23647825]
Molecular Weight

230.26

Formula

C14H14O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=CC(C)=CC(OC2=CC(O)=CC(C)=C2)=C1
Structure Classification
Initial Source

A. sydowii DL1045
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (542.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.3429 mL 21.7146 mL 43.4292 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3429 mL 21.7146 mL 43.4292 mL 108.5729 mL
5 mM 0.8686 mL 4.3429 mL 8.6858 mL 21.7146 mL
10 mM 0.4343 mL 2.1715 mL 4.3429 mL 10.8573 mL
15 mM 0.2895 mL 1.4476 mL 2.8953 mL 7.2382 mL
20 mM 0.2171 mL 1.0857 mL 2.1715 mL 5.4286 mL
25 mM 0.1737 mL 0.8686 mL 1.7372 mL 4.3429 mL
30 mM 0.1448 mL 0.7238 mL 1.4476 mL 3.6191 mL
40 mM 0.1086 mL 0.5429 mL 1.0857 mL 2.7143 mL
50 mM 0.0869 mL 0.4343 mL 0.8686 mL 2.1715 mL
60 mM 0.0724 mL 0.3619 mL 0.7238 mL 1.8095 mL
80 mM 0.0543 mL 0.2714 mL 0.5429 mL 1.3572 mL
100 mM 0.0434 mL 0.2171 mL 0.4343 mL 1.0857 mL
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Diorcinol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Diorcinol20282-75-1Phosphatasechemical epigenetic regulation (CER)protein tyrosine phosphatases (PTPs)Aspergillus sydowiisecondary metabolites (SMs)Inhibitorinhibitorinhibit

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