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Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active.

For research use only. We do not sell to patients.

Dioxone Chemical Structure

Dioxone Chemical Structure

CAS No. : 702-54-5

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1 mg USD 125 In-stock
5 mg USD 375 In-stock
10 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

Dioxone Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Dioxone is a substance possessing convulsant properties qualitatively similar to leptazol and bemegride. Dioxone is orally active[1].

In Vitro

Dioxone is soluble in ethanol, ether, chloroform and propylene glycol. A 1 percent aqueous solution may be obtained at room temperature giving a pH of 4.3, and, with warming to 50℃, 2 percent aqueous solutions may be prepared[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dioxone Related Antibodies
In Vivo

Dioxone (0-30 mg/kg; i.v., i.p., oral, s.c.; once) induces convulsant action[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CF-1 Mice and CF-Wistar rats[1]
Dosage: 0-30 mg/kg
Administration: Intraperitoneal injection, once
Result: In mice: The spontaneous activity was often reduced, always accompanied by hyperreactivity at 10 mg/kg, tremors, clonic convulsion and motor incoordination phenomena occured after the administration of 30 mg/kg. In rats: Tremors and some isolated clonus of the muscles of the limbs were observed with 10 mg/kg, clonic convukions occurred with doses above 15 mg/kg.
Molecular Weight

171.19

Formula

C8H13NO3
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(OCC(CC)1CC)NC1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (584.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.8415 mL 29.2073 mL 58.4146 mL
5 mM 1.1683 mL 5.8415 mL 11.6829 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (14.60 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.8415 mL 29.2073 mL 58.4146 mL 146.0366 mL
5 mM 1.1683 mL 5.8415 mL 11.6829 mL 29.2073 mL
10 mM 0.5841 mL 2.9207 mL 5.8415 mL 14.6037 mL
15 mM 0.3894 mL 1.9472 mL 3.8943 mL 9.7358 mL
20 mM 0.2921 mL 1.4604 mL 2.9207 mL 7.3018 mL
25 mM 0.2337 mL 1.1683 mL 2.3366 mL 5.8415 mL
30 mM 0.1947 mL 0.9736 mL 1.9472 mL 4.8679 mL
40 mM 0.1460 mL 0.7302 mL 1.4604 mL 3.6509 mL
50 mM 0.1168 mL 0.5841 mL 1.1683 mL 2.9207 mL
60 mM 0.0974 mL 0.4868 mL 0.9736 mL 2.4339 mL
80 mM 0.0730 mL 0.3651 mL 0.7302 mL 1.8255 mL
100 mM 0.0584 mL 0.2921 mL 0.5841 mL 1.4604 mL
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Dioxone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dioxone702-54-5OthersCF-1 MiceCF-Wistar ratsHyperreactivityInhibitorinhibitorinhibit

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